UniProt Accession

 PTH_ECOLI; P0A7D1; P23932 

Genbank Protein ID

 X61941; U00096; AP009048 

Genbank Nucleotide ID

 CAA43945.1; AAC74288.1; BAA36062.1 

Protein Name

 Peptidyl-tRNA hydrolase 

Protein Synonyms/Alias

 PTH 

Gene Name

 pth 

Gene Synonyms/Alias

 b1204; JW1195 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
44	APLREEAKFFGYTSR	acetylation	[1]
104	DLPPGVAKFKLGGGH	acetylation	[1]
106	PPGVAKFKLGGGHGG	acetylation	[1]
118	HGGHNGLKDIISKLG	acetylation	[1]
123	GLKDIISKLGNNPNF	acetylation	[1]
153	VVGFVLGKPPVSEQK	acetylation	[1]
160	KPPVSEQKLIDEAID	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis. Involved in lambda inhibition of host protein synthesis. PTH activity may, directly or indirectly, be the target for lambda bar RNA leading to rap cell death. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004045; F:aminoacyl-tRNA hydrolase activity; IDA:EcoCyc.
 GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; IDA:EcoCyc. 

Interpro

 IPR001328; Pept_tRNA_hydro.
 IPR018171; Pept_tRNA_hydro_CS. 

Pfam

 PF01195; Pept_tRNA_hydro 

SMART

  

PROSITE

 PS01195; PEPT_TRNA_HYDROL_1
 PS01196; PEPT_TRNA_HYDROL_2 

PRINTS