Tag | Content |
---|
CPLM ID | CPLM-009518 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongation factor 1-alpha 2 |
Protein Synonyms/Alias | EF-1-alpha-2; Eukaryotic elongation factor 1 A-2; eEF1A-2; Statin-S1 |
Gene Name | Eef1a2 |
Gene Synonyms/Alias | Eef1al; Stn |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
---|
154 | QLIVGVNKMDSTEPA | ubiquitination | [1] | 165 | TEPAYSEKRYDEIVK | ubiquitination | [1] | 172 | KRYDEIVKEVSAYIK | ubiquitination | [1] | 219 | KGWKVERKEGNASGV | ubiquitination | [1] | 386 | IDRRSGKKLEDNPKS | ubiquitination | [1] | 392 | KKLEDNPKSLKSGDA | ubiquitination | [1] | 439 | TVAVGVIKNVEKKSG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. |
Sequence Annotation | NP_BIND 14 21 GTP (By similarity). NP_BIND 91 95 GTP (By similarity). NP_BIND 153 156 GTP (By similarity). MOD_RES 29 29 Phosphotyrosine. MOD_RES 55 55 N6,N6,N6-trimethyllysine (By similarity). MOD_RES 141 141 Phosphotyrosine. MOD_RES 165 165 N6,N6,N6-trimethyllysine (By similarity). MOD_RES 179 179 N6-acetyllysine (By similarity). MOD_RES 301 301 5-glutamyl glycerylphosphorylethanolamine MOD_RES 374 374 5-glutamyl glycerylphosphorylethanolamine MOD_RES 439 439 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Direct protein sequencing; Elongation factor; GTP-binding; Methylation; Nucleotide-binding; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 463 AA |
Protein Sequence | MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG KGSFKYAWVL 60 DKLKAERERG ITIDISLWKF ETTKYYITII DAPGHRDFIK NMITGTSQAD CAVLIVAAGV 120 GEFEAGISKN GQTREHALLA YTLGVKQLIV GVNKMDSTEP AYSEKRYDEI VKEVSAYIKK 180 IGYNPATVPF VPISGWHGDN MLEPSPNMPW FKGWKVERKE GNASGVSLLE ALDTILPPTR 240 PTDKPLRLPL QDVYKIGGIG TVPVGRVETG ILRPGMVVTF APVNITTEVK SVEMHHEALS 300 EALPGDNVGF NVKNVSVKDI RRGNVCGDSK ADPPQEAAQF TSQVIILNHP GQISAGYSPV 360 IDCHTAHIAC KFAELKEKID RRSGKKLEDN PKSLKSGDAA IVEMVPGKPM CVESFSQYPP 420 LGRFAVRDMR QTVAVGVIKN VEKKSGGAGK VTKSAQKAQK AGK 463 |
Gene Ontology | GO:0005853; C:eukaryotic translation elongation factor 1 complex; IDA:MGI. GO:0043025; C:neuronal cell body; IEA:Compara. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IEA:InterPro. GO:0003746; F:translation elongation factor activity; IDA:MGI. GO:0006184; P:GTP catabolic process; IEA:GOC. GO:0043066; P:negative regulation of apoptotic process; IDA:MGI. GO:0010035; P:response to inorganic substance; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |