CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020756
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphomevalonate kinase 
Protein Synonyms/Alias
 PMKase 
Gene Name
 Pmvk 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
48LRLSGPLKEEYAREHubiquitination[1]
69LLDASTYKETYRRDMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 NP_BIND 17 23 ATP (By similarity).
 MOTIF 190 192 Microbody targeting signal (Potential).
 BINDING 141 141 ATP (By similarity).
 BINDING 170 170 Substrate (By similarity).
 BINDING 171 171 ATP (By similarity).
 BINDING 180 180 ATP (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Kinase; Lipid biosynthesis; Lipid metabolism; Nucleotide-binding; Peroxisome; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 192 AA 
Protein Sequence
MAPLGASPRL VLLFSGKRKS GKDFVTERLK SRLGGNICAL LRLSGPLKEE YAREHGLDFQ 60
RLLDASTYKE TYRRDMICWG EQKRQADPGF FCRKIVEGVS QPIWLVSDTR RTSDIQWFQE 120
AYGAVIQTVR VVASEQSRQQ RGWVFTPGVD DAESECGLDN FGNFDWVIEN HGDEQCLEDQ 180
LEHLLGFIQA KL 192 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004631; F:phosphomevalonate kinase activity; IDA:MGI.
 GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
 GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniPathway.
 GO:0070723; P:response to cholesterol; IEA:Compara. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005919; Pmev_kin_anim. 
Pfam
 PF04275; P-mevalo_kinase 
SMART
  
PROSITE
  
PRINTS