UniProt Accession

 RL25_ECOLI; P68919; P02426; Q2MAQ6 

Genbank Protein ID

 D13326; U00008; U00096; AP009048 

Genbank Nucleotide ID

 BAA02585.1; AAA16413.1; AAC75246.1; BAE76650.1 

Protein Name

 50S ribosomal protein L25 

Protein Synonyms/Alias

  

Gene Name

 rplY 

Gene Synonyms/Alias

 b2185; JW2173 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
25	RRLRAANKFPAIIYG	acetylation	[1]
34	PAIIYGGKEAPLAIE	acetylation	[1]
34	PAIIYGGKEAPLAIE	pupylation	[2]
46	AIELDHDKVMNMQAK	acetylation	[1]
68	LTIVVDGKEIKVKAQ	acetylation	[1]
71	VVDGKEIKVKAQDVQ	acetylation	[1]
73	DGKEIKVKAQDVQRH	acetylation	[1]
83	DVQRHPYKPKLQHID	acetylation	[1, 3]
85	QRHPYKPKLQHIDFV	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.
 Cerda-Maira FA, McAllister F, Bode NJ, Burns KE, Gygi SP, Darwin KH.
 EMBO Rep. 2011 Jul 8;12(8):863-70. [PMID: 21738222]
 [3] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Binds to the 5S rRNA independently of L5 and L18. Not required for binding of the 5S rRNA/L5/L18 subcomplex to 23S rRNA. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 94 AA 

Protein Sequence

Gene Ontology

 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0008097; F:5S rRNA binding; IEA:InterPro.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:HAMAP. 

Interpro

 IPR020056; Rbsml_L25/Gln-tRNA_synth_b-brl.
 IPR011035; Ribosomal_L25/Gln-tRNA_synth.
 IPR020055; Ribosomal_L25_short. 

Pfam

 PF01386; Ribosomal_L25p 

SMART

  

PROSITE

  

PRINTS