CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029022
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongation factor 1-alpha 
Protein Synonyms/Alias
  
Gene Name
 Ef1alpha100E 
Gene Synonyms/Alias
 CG1873; Dmel_CG1873 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
30TTGHLIYKCGGIDKRacetylation[1]
41IDKRTIEKFEKEAQEacetylation[1]
44RTIEKFEKEAQEMGKacetylation[1]
55EMGKGSFKYAWVLDKacetylation[1]
172ARYEEIKKEVSSYIKacetylation[1]
255LPLQDVYKIGGIGTVacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Elongation factor; GTP-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 462 AA 
Protein Sequence
MGKEKIHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAQEMG KGSFKYAWVL 60
DKLKAERERG ITIDIALWKF ETSKYYVTII DAPGHRDFIK NMITGTSQAD CAVLIVAAGT 120
GEFEAGISKN GQTREHALLA FTLGVKQLIV GVNKMDSTEP PYSEARYEEI KKEVSSYIKK 180
IGYNPASVAF VPISGWHGDN MLEPSEKMPW FKGWSVERKE GKAEGKCLID ALDAILPPQR 240
PTDKPLRLPL QDVYKIGGIG TVPVGRVETG LLKPGMVVNF APVNLVTEVK SVEMHHEALT 300
EAMPGDNVGF NVKNVSVKEL RRGYVAGDSK NNPPRGAADF TAQVIVLNHP GQIANGYTPV 360
LDCHTAHIAC KFSEIKEKCD RRTGKTTETE PKAIKSGDAA IIVLVPSKPL CVESFQEFPP 420
LGRFAVRDMR QTVAVGVIKS VNFKETTSGK VTKAAEKAQK KK 462 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004539; Transl_elong_EF1A_euk/arc.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR004160; Transl_elong_EFTu/EF1A_C.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2
 PF03143; GTP_EFTU_D3 
SMART
  
PROSITE
 PS00301; EFACTOR_GTP 
PRINTS
 PR00315; ELONGATNFCT.