CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007654
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycerol-3-phosphate dehydrogenase, mitochondrial 
Protein Synonyms/Alias
 GPD-M; GPDH-M; mtGPD 
Gene Name
 GPD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
83EHFPMLQKDKLVGAIubiquitination[1]
128MEVVSLLKKTDPQTGubiquitination[1]
347GLFLQGGKDWSPTLYubiquitination[1]
378LAATYGDKAFEVAKMubiquitination[1]
384DKAFEVAKMASVTGKubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
 DOMAIN 623 658 EF-hand 1.
 DOMAIN 659 694 EF-hand 2.
 NP_BIND 71 99 FAD (Potential).
 MOD_RES 600 600 Phosphotyrosine (By similarity).
 MOD_RES 601 601 Phosphotyrosine (By similarity).  
Keyword
 Alternative splicing; Calcium; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Metal-binding; Mitochondrion; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 727 AA 
Protein Sequence
MKLDIEQYRM VKEALHERAN LLEIAPHLSA PLPIMLPVYK WWQLPYYWVG IKLYDLVAGS 60
NCLKSSYVLS KSRALEHFPM LQKDKLVGAI VYYDGQHNDA RMNLAIALTA ARYGAATANY 120
MEVVSLLKKT DPQTGKVRVS GARCKDVLTG QEFDVRAKCV INATGPFTDS VRKMDDKDAA 180
AICQPSAGVH IVMPGYYSPE SMGLLDPATS DGRVIFFLPW QKMTIAGTTD TPTDVTHHPI 240
PSEEDINFIL NEVRNYLSCD VEVRRGDVLA AWSGIRPLVT DPKSADTQSI SRNHVVDISE 300
SGLITIAGGK WTTYRSMAED TINAAVKTHN LKAGPSRTVG LFLQGGKDWS PTLYIRLVQD 360
YGLESEVAQH LAATYGDKAF EVAKMASVTG KRWPIVGVRL VSEFPYIEAE VKYGIKEYAC 420
TAVDMISRRT RLAFLNVQAA EEALPRIVEL MGRELNWDDY KKQEQLETAR KFLYYEMGYK 480
SRSEQLTDRS EISLLPSDID RYKKRFHKFD ADQKGFITIV DVQRVLESIN VQMDENTLHE 540
ILNEVDLNKN GQVELNEFLQ LMSAIQKGRV SGSRLAILMK TAEENLDRRV PIPVDRSCGG 600
L 601 
Gene Ontology
 GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0005509; F:calcium ion binding; TAS:ProtInc.
 GO:0004368; F:glycerol-3-phosphate dehydrogenase activity; TAS:ProtInc.
 GO:0052591; F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity; IEA:EC.
 GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.
 GO:0006094; P:gluconeogenesis; IEA:Compara.
 GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR006076; FAD-dep_OxRdtase.
 IPR000447; G3P_DH_FAD-dep. 
Pfam
 PF01266; DAO
 PF13499; EF_hand_5 
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS00977; FAD_G3PDH_1
 PS00978; FAD_G3PDH_2 
PRINTS
 PR01001; FADG3PDH.