CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005304
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 4A12 
Protein Synonyms/Alias
 CYPIVA12; CYPIVA8; Cytochrome P450-KP1; Cytochrome P450-PP1 
Gene Name
 Cyp4a12 
Gene Synonyms/Alias
 Cyp4a-8; Cyp4a8 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
154AFHYDTLKPYVGIMAacetylation[1]
497PRLVLKSKNGIYLRLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 
Sequence Annotation
 METAL 455 455 Iron (heme axial ligand).
 BINDING 319 319 Heme (covalent; via 1 link).  
Keyword
 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 508 AA 
Protein Sequence
MSGSALSFTI FPGSILGFLQ IATVLTVLLL LFKTAQFYLH RRWLLRATQQ FPSPPSHWFF 60
GHKIPKDQEF QDILTRVKNF PSACPQWLWG SNVRIQVYDP DYMKLILGRS DPKSHHSYRF 120
LAPWIGYGLL LLNGQTWFQH RRMLTPAFHY DTLKPYVGIM ADSVRIMLDK WEQIVGQDST 180
LEIFQHITLM TLDTIMKCAF SQEGSVQLDR KYKSYIKAVE DLNNLSFFRI RNIFHQNDII 240
YSLSSNGRKA RSAWQLAHEH TDQVIKSRKA QLQDEEELQK VKQKRRLDFL DILLFARIEN 300
GSSLSDKDLR AEVDTFMFEG HDTTASGISW IFYALATNPE HQQGCRKEIQ SLLGDGASIT 360
WDDLDKMPYT TMCIKEALRI YPPVTAVSRM LSTPVTFPDG RSLPKGITVM LSFYGLHHNP 420
TVWPNPEVFD PYRFAPESSR HSHSFLPFSG GARNCIGKQF AMNELKVAVA LTLLRFELLP 480
DPTRIPIPIP RLVLKSKNGI YLRLKKLQ 508 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0043231; C:intracellular membrane-bounded organelle; TAS:UniProtKB.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004497; F:monooxygenase activity; IDA:UniProtKB.
 GO:0019369; P:arachidonic acid metabolic process; IDA:RGD.
 GO:0001822; P:kidney development; IEP:RGD.
 GO:0048252; P:lauric acid metabolic process; IDA:RGD.
 GO:0033574; P:response to testosterone stimulus; IEP:RGD. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.