UniProt Accession

 RABEK_HUMAN; Q7Z6M1; A8K403; O00568; Q69YR2; Q6FHA4; Q6IBG7; Q6P092; Q86Y76; Q9BWB1 

Genbank Protein ID

 Z97074; AK290768; CR456837; CR541851; AL354710; AL445930; AL445930; AL354710; CH471090; BC000503; BC047023; BC053541; BC065725; AL832249 

Genbank Nucleotide ID

 CAB09808.1; BAF83457.1; CAG33118.1; CAG46649.1; CAQ08743.1; CAQ08743.1; CAI13681.1; CAI13681.1; EAW87616.1; AAH00503.1; AAH47023.1; AAH53541.1; AAH65725.1; CAH10393.1 

Protein Name

 Rab9 effector protein with kelch motifs 

Protein Synonyms/Alias

 40 kDa Rab9 effector protein; p40 

Gene Name

 RABEPK 

Gene Synonyms/Alias

 RAB9P40 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	EPGDKPRKATWYTLT	ubiquitination	[1]
46	LPPVGNAKRGKVFIV	ubiquitination	[1]
49	VGNAKRGKVFIVGGA	ubiquitination	[1, 2]
72	VHTMDLGKHQWDLDT	ubiquitination	[1]
81	QWDLDTCKGLLPRYE	ubiquitination	[1]
169	AQPVQDTKLHVFDAN	ubiquitination	[2]
232	ISDMKWQKLNPTGAA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Rab9 effector required for endosome to trans-Golgi network (TGN) transport. 

Sequence Annotation

 REPEAT 49 95 Kelch 1.
 REPEAT 100 146 Kelch 2.
 REPEAT 151 200 Kelch 3.
 REPEAT 204 250 Kelch 4.
 REPEAT 254 303 Kelch 5.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Endosome; Kelch repeat; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 372 AA 

Protein Sequence

Gene Ontology

 GO:0005768; C:endosome; TAS:ProtInc.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc.
 GO:0006904; P:vesicle docking involved in exocytosis; TAS:ProtInc. 

Interpro

 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1.
 IPR011498; Kelch_2. 

Pfam

 PF01344; Kelch_1
 PF07646; Kelch_2 

SMART

  

PROSITE

  

PRINTS