| Tag | Content |
|---|
| CPLM ID | CPLM-010412 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acid-sensing ion channel 1 |
Protein Synonyms/Alias | ASIC1; Amiloride-sensitive cation channel 2, neuronal; Brain sodium channel 2; BNaC2 |
Gene Name | ASIC1 |
Gene Synonyms/Alias | ACCN2; BNAC2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 193 | VVFTRYGKCYTFNSG | ubiquitination | [1] | | 374 | CNLTRYGKELSMVKI | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear (By similarity). |
Sequence Annotation | MOD_RES 479 479 Phosphoserine; by PKA.
CARBOHYD 368 368 N-linked (GlcNAc...) (Potential).
CARBOHYD 395 395 N-linked (GlcNAc...) (Potential).
DISULFID 93 194 By similarity.
DISULFID 172 179 By similarity.
DISULFID 290 367 By similarity.
DISULFID 310 363 By similarity.
DISULFID 314 361 By similarity.
DISULFID 323 345 By similarity.
DISULFID 325 337 By similarity. |
Keyword | Alternative splicing; Calcium; Calcium transport; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 528 AA |
Protein Sequence | MELKAEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF LGSLAVLLCV 60
CTERVQYYFH YHHVTKLDEV AASQLTFPAV TLCNLNEFRF SQVSKNDLYH AGELLALLNN 120
RYEIPDTQMA DEKQLEILQD KANFRSFKPK PFNMREFYDR AGHDIRDMLL SCHFRGEVCS 180
AEDFKVVFTR YGKCYTFNSG RDGRPRLKTM KGGTGNGLEI MLDIQQDEYL PVWGETDETS 240
FEAGIKVQIH SQDEPPFIDQ LGFGVAPGFQ TFVACQEQRL IYLPPPWGTC KAVTMDSDLD 300
FFDSYSITAC RIDCETRYLV ENCNCRMVHM PGDAPYCTPE QYKECADPAL DFLVEKDQEY 360
CVCEMPCNLT RYGKELSMVK IPSKASAKYL AKKFNKSEQY IGENILVLDI FFEVLNYETI 420
EQKKAYEIAG LLGELLMTPV PFSCHGHGVA PYHPKAGCSL LSHEGPPPQR PFPKPCCLGD 480
IGGQMGLFIG ASILTVLELF DYAYEVIKHK LCRRGKCQKE AKRSSADKGV ALSLDDVKRH 540
NPCESLRGHP AGMTYAANIL PHHPARGTFE DFTC 574 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0045202; C:synapse; IEA:Compara. GO:0015280; F:ligand-gated sodium channel activity; NAS:UniProtKB. GO:0008306; P:associative learning; IEA:Compara. GO:0070588; P:calcium ion transmembrane transport; IEA:Compara. GO:0007613; P:memory; IEA:Compara. GO:0046929; P:negative regulation of neurotransmitter secretion; IEA:Compara. GO:0042391; P:regulation of membrane potential; IEA:Compara. GO:0001101; P:response to acid; IEA:Compara. GO:0009268; P:response to pH; TAS:ProtInc. GO:0007165; P:signal transduction; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |