CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017398
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ligand of Numb protein X 2 
Protein Synonyms/Alias
 Numb-binding protein 2; PDZ domain-containing RING finger protein 1 
Gene Name
 LNX2 
Gene Synonyms/Alias
 PDZRN1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
423LTIARPGKPQPGNTIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 233 318 PDZ 1.
 DOMAIN 339 422 PDZ 2.
 DOMAIN 468 554 PDZ 3.
 DOMAIN 600 688 PDZ 4.
 ZN_FING 50 88 RING-type.
 MOTIF 208 211 NPXY motif.  
Keyword
 3D-structure; Complete proteome; Metal-binding; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 690 AA 
Protein Sequence
MGTTSDEMVS VEQTSSSSLN PLCFECGQQH WTRENHLYNY QNEVDDDLVC HICLQPLLQP 60
LDTPCGHTFC YKCLRNFLQE KDFCPLDRKR LHFKLCKKSS ILVHKLLDKL LVLCPFSSVC 120
KDVMQRCDLE AHLKNRCPGA SHRRVALERR KTSRTQAEIE NENGPTLLDP AGTLSPEADC 180
LGTGAVPVER HLTSASLSTW SEEPGLDNPA FEESAGADTT QQPLSLPEGE ITTIEIHRSN 240
PYIQLGISIV GGNETPLINI VIQEVYRDGV IARDGRLLAG DQILQVNNYN ISNVSHNYAR 300
AVLSQPCNTL HLTVLRERRF GNRAHNHSDS NSPREEIFQV ALHKRDSGEQ LGIKLVRRTD 360
EPGVFILDLL EGGLAAQDGR LSSNDRVLAI NGHDLKYGTP ELAAQIIQAS GERVNLTIAR 420
PGKPQPGNTI REAGNHSSSS QHHTPPPYYS RPSSHKDLTQ CVTCQEKHIT VKKEPHESLG 480
MTVAGGRGSK SGELPIFVTS VPPHGCLARD GRIKRGDVLL NINGIDLTNL SHSEAVAMLK 540
ASAASPAVAL KALEVQIVEE ATQNAEEQPS TFSENEYDAS WSPSWVMWLG LPSTLHSCHD 600
IVLRRSYLGS WGFSIVGGYE ENHTNQPFFI KTIVLGTPAY YDGRLKCGDM IVAVNGLSTV 660
GMSHSALVPM LKEQRNKVTL TVICWPGSLV 690 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0051260; P:protein homooligomerization; IEA:Compara. 
Interpro
 IPR001478; PDZ.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00595; PDZ 
SMART
 SM00228; PDZ
 SM00184; RING 
PROSITE
 PS50106; PDZ
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS