CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023702
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform 
Protein Synonyms/Alias
 IMYPNO1; PP2A subunit B isoform B55-gamma; PP2A subunit B isoform PR55-gamma; PP2A subunit B isoform R2-gamma; PP2A subunit B isoform gamma 
Gene Name
 PPP2R2C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
263ALCDKHSKLFEEPEDubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. 
Sequence Annotation
 REPEAT 22 61 WD 1.
 REPEAT 87 128 WD 2.
 REPEAT 171 209 WD 3.
 REPEAT 220 260 WD 4.
 REPEAT 279 317 WD 5.
 REPEAT 334 375 WD 6.
 REPEAT 410 446 WD 7.  
Keyword
 Alternative splicing; Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 447 AA 
Protein Sequence
MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA 60
PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI 120
TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRIFAN GHTYHINSIS 180
VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY 240
SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD 300
YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD SVIMTGAYNN 360
FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW 420
HPAENIIAIA ATNNLYIFQD KVNSDMH 447 
Gene Ontology
 GO:0000159; C:protein phosphatase type 2A complex; NAS:UniProtKB.
 GO:0008601; F:protein phosphatase type 2A regulator activity; NAS:UniProtKB.
 GO:0007165; P:signal transduction; NAS:UniProtKB. 
Interpro
 IPR000009; PP2A_PR55.
 IPR018067; PP2A_PR55_CS.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
  
SMART
 SM00320; WD40 
PROSITE
 PS01024; PR55_1
 PS01025; PR55_2
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00600; PP2APR55.