| Tag | Content |
|---|
| CPLM ID | CPLM-000374 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A |
Protein Synonyms/Alias | PP6-ARS-A; Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A; Ankyrin repeat domain-containing protein 28; Phosphatase interactor targeting protein hnRNP K; PITK |
Gene Name | ANKRD28 |
Gene Synonyms/Alias | KIAA0379 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 106 | RVNAKDSKWLTPLHR | ubiquitination | [1] |
|
Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. |
Sequence Annotation | REPEAT 40 69 ANK 1.
REPEAT 73 102 ANK 2.
REPEAT 106 135 ANK 3.
REPEAT 139 168 ANK 4.
REPEAT 172 201 ANK 5.
REPEAT 205 234 ANK 6.
REPEAT 238 267 ANK 7.
REPEAT 271 301 ANK 8.
REPEAT 305 334 ANK 9.
REPEAT 338 367 ANK 10.
REPEAT 371 400 ANK 11.
REPEAT 404 433 ANK 12.
REPEAT 437 466 ANK 13.
REPEAT 470 500 ANK 14.
REPEAT 504 534 ANK 15.
REPEAT 549 578 ANK 16.
REPEAT 582 611 ANK 17.
REPEAT 616 645 ANK 18.
REPEAT 652 681 ANK 19.
REPEAT 685 714 ANK 20.
REPEAT 718 747 ANK 21.
REPEAT 755 784 ANK 22.
REPEAT 787 817 ANK 23.
REPEAT 822 851 ANK 24.
REPEAT 855 885 ANK 25.
REPEAT 889 918 ANK 26.
REPEAT 925 954 ANK 27.
MOD_RES 84 84 Phosphoserine (By similarity).
MOD_RES 1007 1007 Phosphoserine.
MOD_RES 1011 1011 Phosphoserine. |
Keyword | Alternative promoter usage; Alternative splicing; ANK repeat; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1053 AA |
Protein Sequence | MSRVCIVVLE EVEDESPAFI SKLPQENKSL HSPPSGNVLV RYPSLVQAIF NGDPDEVRAL 60
IFKKEDVNFQ DNEKRTPLHA AAYLGDAEII ELLILSGARV NAKDSKWLTP LHRAVASCSE 120
EAVQVLLKHS ADVNARDKNW QTPLHIAAAN KAVKCAEALV PLLSNVNVSD RAGRTALHHA 180
AFSGHGEMVK LLLSRGANIN AFDKKDRRAI HWAAYMGHIE VVKLLVSHGA EVTCKDKKSY 240
TPLHAAASSG MISVVKYLLD LGVDMNEPNA YGNTPLHVAC YNGQDVVVNE LIDCGAIVNQ 300
KNEKGFTPLH FAAASTHGAL CLELLVGNGA DVNMKSKDGK TPLHMTALHG RFSRSQTIIQ 360
SGAVIDCEDK NGNTPLHIAA RYGHELLINT LITSGADTAK RGIHGMFPLH LAALSGFSDC 420
CRKLLSSGFD IDTPDDFGRT CLHAAAAGGN LECLNLLLNT GADFNKKDKF GRSPLHYAAA 480
NCNYQCLFAL VGSGASVNDL DERGCTPLHY AATSDTDGKC LEYLLRNDAN PGIRDKQGYN 540
AVHYSAAYGH RLCLQLIASE TPLDVLMETS GTDMLSDSDN RATISPLHLA AYHGHHQALE 600
VLVQSLLDLD VRNSSGRTPL DLAAFKGHVE CVDVLINQGA SILVKDYILK RTPIHAAATN 660
GHSECLRLLI GNAEPQNAVD IQDGNGQTPL MLSVLNGHTD CVYSLLNKGA NVDAKDKWGR 720
TALHRGAVTG HEECVDALLQ HGAKCLLRDS RGRTPIHLSA ACGHIGVLGA LLQSAASMDA 780
NPATADNHGY TALHWACYNG HETCVELLLE QEVFQKTEGN AFSPLHCAVI NDNEGAAEML 840
IDTLGASIVN ATDSKGRTPL HAAAFTDHVE CLQLLLSHNA QVNSVDSTGK TPLMMAAENG 900
QTNTVEMLVS SASAELTLQD NSKNTALHLA CSKGHETSAL LILEKITDRN LINATNAALQ 960
TPLHVAARNG LTMVVQELLG KGASVLAVDE NGYTPALACA PNKDVADCLA LILATMMPVS 1020
SSSPLSSLTF NAINRYTNTS KTVSFEALPI MRNEPSSYCS FNNIGGEQEY LYTDVDELND 1080
SDSETY 1086 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |