CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027294
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin VIIA 
Protein Synonyms/Alias
 Protein Myo7a 
Gene Name
 Myo7a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
2040QVSPDDWKRSIVAYFacetylation[1]
2049SIVAYFNKHAGKSKEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2177 AA 
Protein Sequence
MVILQKGDYV WMDLKSGQEF DVPIGAMVKL CESGQIQVVD DEGNEHWISP QNATHIKPMH 60
PTSVHGVEDM IRLGDLNEAG ILRNLLIRYR DHLIYTYTGS ILVAVNPYQL LSIYSSEHIR 120
QYTNKKIGEM PPHIFAIADN CYFNMKRNNR DQCCIISGES GAGKTESTKL ILQFLAAISG 180
QHSWIEQQVL EATPILEAFG NAKTIRNDNS SRFGKYIDIH FNKRGAIEGA KIEQYLLEKS 240
RVCRQAPDER NYHVFYCMLE GMNEEEKKKL GLGQAADYNY LAMGNCITCE GRVDSQEYAN 300
IRSAMKVLMF TDTENWEILK LLAAILHMGN LQYEARTFEN LDACEVLFSP SLATAASHLE 360
VNPPDLMSCL TSRTLITRGE TVSTPLSREQ ALDVRDAFVK GIYGRLFVWI VEKINAAIYK 420
PPSQEVTNSR RSIGLLDIFG FENFTVNSFE QLCINFANEH LQQFFVRHVF KLEQEEYDLE 480
SIDWLHIEFT DNQEALDMIA NRPMNVISLI DEESKFPKGT DATMLHKLNS QHRLNANYVP 540
PKNSHETQFG INHFAGIVYY ESQGFLEKNR DTLHGDIIQL VHSSRNKFVK QIFQADVAMG 600
AETRKRSPTL SSQFKRSLEL LMRTLGACQP FFVRCIKPNE FKKPMLFDRH LCVRQLRYSG 660
MMETIRIRHA GYPIRYSFVE FVERYRVLLP GVKPAYKQDD LQGTCQRMAE AVLGTHDDWQ 720
IGKTKIFLKD HHDMLLEVER DKAITDRVIL LQKVIRGFKD RSNFLRLKSA ATLIQRHWRG 780
HHCRKNYELI RLGFLRLQAL HRSRKLHKQY RLARQRIIKF QARCRAYLVR RAFRHRLWAV 840
ITVQAYARGM IARRLHRRLR VEYWRRLEAE RMRLAEEEKL RKEMSAKKAK EEAERKHQER 900
LAQLAREDAE RELKEKEEAR RKKELLQQME RARHEPINHS DMVDKMFGFL GTSSGLPGQE 960
GQAPSGFEDL ERGRREMVEE DVDAALPLPD EDEEDLSEYK FAKFAATYFQ GTTTHSYTRR 1020
PLKQPLLYHD DEGDQLAALA VWITILRFMG DLPEPKYHTA MSDGSEKIPV MTKIYETLGK 1080
KTYKRELQAL QGEGEAQLSE GQKKTSVKHK LVHLTLKKKS KLTEEVTKRL HDGESMVQGN 1140
SMLEDRPTSN LEKLHFIIGN GILRPALRDE IYCQISKQLT HNPSKSSYAR GWILVSLCVG 1200
CFAPSEKFVK YLRNFIHGGP PGYAPYCEER LRRTFVNGTR TQPPSWLELQ ATKSKKPIML 1260
PVTFMDGTTK TLLADSATTA KELCNALADK ISLKDRFGFS LYIALFDKVS SLGSGSDHVM 1320
DAISQCEQYA KEQGAQERNA PWRLFFRKEV FTPWHNPSED NVATNLIYQQ VVRGVKFGEY 1380
RCEKEDDLAE LASQQYFVDY GSEMILERLL SLVPTYIPDR EITPLKNLEK WAQLAIAAHK 1440
KGIYAQRRTD AQKVKQDVVN YARFKWPLLF SRFYEAYKFS GPPLPKSDVI VAVNWTGVYF 1500
VDEQEQVLLE LSFPEIMAVS SSRGAKLMAP SFTLATIKGD EYTFTSSNAE DIRDLVVTFL 1560
EGLRKRSKYV VALQDNPNPA GEESGFLSFA KGDLIILDHD TGEQVMNSGW ANGINERTKQ 1620
RGDFPTDCVY VMPTVTLPPR EIVALVTMTP DQRQDVVRLL QLRTAEPEVR TKPYTLEEFS 1680
YDYFRSPPKH TLSRVMVSKA RGKDRLWSHT REPLKQALLK KIVGSEELSQ EACMSFIAVL 1740
KYMGDYPSKR TRSVNELTDQ IFEWAVKAEP LKDEAYVQIL KQLTDNHIRY SEEKGWELLW 1800
LCTGLFPPSN ILLPHVQRFL QSRKHCPLAI DCLQRLQKAL RNGSRKYPPH LVEVEAIQHK 1860
TTQIFHKVYF PDDTDEAFEV ESSTKAKDFC QNIASRLLLK SSEGFSLFVK IADKVISVPE 1920
NDFFFDFVRH LTDWIKKARP IKDGIVPSLT YQVFFMKKLW TTTVPGKDPM ADSIFHYYQE 1980
LPKYLRGYHK CTREEVLQLG ALIYRVKFEE DKSYFPSIPK LLRELVPQDL IRQVSPDDWK 2040
RSIVAYFNKH AGKSKEEAKL AFLKLIFKWP TFGSAFFEVK QTTEPNFPEI LLIAINKYGI 2100
SLIDPRTKDI LTTHPFTKIS NWSSGNTYFH ITIGNLVRGS KLLCETSLGY KMDDLLTSYI 2160
SQMLTAMSKQ RNSRSGR 2177 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
 GO:0042470; C:melanosome; IEA:Compara.
 GO:0005902; C:microvillus; IDA:MGI.
 GO:0031477; C:myosin VII complex; IDA:RGD.
 GO:0032391; C:photoreceptor connecting cilium; IEA:Compara.
 GO:0001917; C:photoreceptor inner segment; ISS:UniProtKB.
 GO:0001750; C:photoreceptor outer segment; ISS:UniProtKB.
 GO:0032420; C:stereocilium; IEA:Compara.
 GO:0045202; C:synapse; ISS:UniProtKB.
 GO:0003779; F:actin binding; IDA:RGD.
 GO:0030898; F:actin-dependent ATPase activity; IDA:RGD.
 GO:0043531; F:ADP binding; IDA:RGD.
 GO:0005524; F:ATP binding; IDA:RGD.
 GO:0005516; F:calmodulin binding; ISS:UniProtKB.
 GO:0000146; F:microfilament motor activity; IEA:Compara.
 GO:0003774; F:motor activity; IDA:RGD.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0030048; P:actin filament-based movement; IDA:RGD.
 GO:0060088; P:auditory receptor cell stereocilium organization; IEA:Compara.
 GO:0050957; P:equilibrioception; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:Compara.
 GO:0007040; P:lysosome organization; ISS:UniProtKB.
 GO:0001845; P:phagolysosome assembly; IEA:Compara.
 GO:0051904; P:pigment granule transport; IEA:Compara.
 GO:0048563; P:post-embryonic organ morphogenesis; IEA:Compara.
 GO:0007605; P:sensory perception of sound; ISS:UniProtKB.
 GO:0007601; P:visual perception; ISS:UniProtKB. 
Interpro
 IPR019749; Band_41_domain.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR000857; MyTH4_dom.
 IPR027417; P-loop_NTPase.
 IPR011993; PH_like_dom.
 IPR001452; SH3_domain. 
Pfam
 PF00373; FERM_M
 PF09379; FERM_N
 PF00612; IQ
 PF00063; Myosin_head
 PF00784; MyTH4 
SMART
 SM00295; B41
 SM00015; IQ
 SM00242; MYSc
 SM00139; MyTH4
 SM00326; SH3 
PROSITE
 PS50057; FERM_3
 PS50096; IQ
 PS51016; MYTH4
 PS50002; SH3 
PRINTS
 PR00193; MYOSINHEAVY.