CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021897
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uroporphyrinogen decarboxylase 
Protein Synonyms/Alias
 UPD; URO-D 
Gene Name
 hemE 
Gene Synonyms/Alias
 STM4167; STMF1.21 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
187LLLDKLAKSVTLYLNacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity). 
Sequence Annotation
 REGION 27 31 Substrate binding (By similarity).
 BINDING 46 46 Substrate (By similarity).
 BINDING 77 77 Substrate (By similarity).
 BINDING 154 154 Substrate (By similarity).
 BINDING 209 209 Substrate (By similarity).
 BINDING 327 327 Substrate (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Decarboxylase; Lyase; Porphyrin biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 354 AA 
Protein Sequence
MTELKNDRYL RALLRQPVDV TPVWMMRRAG RYLPEYKATR AQAGDFMSLC KNAELACEVT 60
LQPLRRYPLD AAILFSDILT IPDAMGLGLY FEAGEGPRFT APVTCKADVE KLPIPDPEGE 120
LGYVMNAVRT IRRELKGEVP LIGFSGSPWT LATYMVEGGS SKAFTVIKKM MYADPQALHL 180
LLDKLAKSVT LYLNAQIKAG AQSVMIFDTW GGVLTGRDYQ QFSLYYMHKI VDGLLRENDG 240
RRVPVTLFTK GGGQWLEAMA ETGCDALGLD WTTDIADARR RVGHKVALQG NMDPSMLYAP 300
PARIEDEVAT ILAGFGQGEG HVFNLGHGIH QDVPPEHAGA FVEAVHRLSA QYHN 354 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:HAMAP.
 GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR006361; Uroporphyrinogen_deCO2ase_HemE.
 IPR000257; Uroporphyrinogen_deCOase. 
Pfam
 PF01208; URO-D 
SMART
  
PROSITE
 PS00906; UROD_1
 PS00907; UROD_2 
PRINTS