| Tag | Content |
|---|
| CPLM ID | CPLM-002545 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 78 kDa glucose-regulated protein |
Protein Synonyms/Alias | GRP-78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP |
Gene Name | HSPA5 |
Gene Synonyms/Alias | GRP78 |
Created Date | July 27, 2013 |
Organism | Mesocricetus auratus (Golden hamster) |
NCBI Taxa ID | 10036 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 573 | ESYAYSLKNQIGDKE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. |
Sequence Annotation | MOTIF 651 654 Prevents secretion from ER.
MOD_RES 160 160 Nitrated tyrosine (By similarity).
MOD_RES 166 166 Phosphothreonine (By similarity).
MOD_RES 518 518 Phosphothreonine (By similarity).
MOD_RES 571 571 Phosphoserine (By similarity).
MOD_RES 585 585 N6,N6,N6-trimethyllysine; by METTL21A; in
MOD_RES 649 649 Phosphoserine (By similarity). |
Keyword | ATP-binding; Cytoplasm; Endoplasmic reticulum; Methylation; Nitration; Nucleotide-binding; Phosphoprotein; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 654 AA |
Protein Sequence | MKFPMVAAAL LLLCAVRAEE EDKKEDVGTV VGIDLGTTYS CVGVFKNGRV EIIANDQGNR 60
ITPSYVAFTP EGERLIGDAA KNQLTSNPEN TVFDAKRLIG RTWNDPSVQQ DIKFLPFKVV 120
EKKTKPYIQV DIGGGQTKTF APEEISAMVL TKMKETAEAY LGKKVTHAVV TVPAYFNDAQ 180
RQATKDAGTI AGLNVMRIIN EPTAAAIAYG LDKREGEKNI LVFDLGGGTF DVSLLTIDNG 240
VFEVVATNGD THLGGEDFDQ RVMEHFIKLY KKKTGKDVRK DNRAVQKLRR EVEKAKRALS 300
SQHQARIEIE SFFEGEDFSE TLTRAKFEEL NMDLFRSTMK PVQKVLEDSD LKKSDIDEIV 360
LVGGSTRIPK IQQLVKEFFN GKEPSRGINP DEAVAYGAAV QAGVLSGDQD TGDLVLLDVC 420
PLTLGIETVG GVMTKLIPRN TVVPTKKSQI FSTASDNQPT VTIKVYEGER PLTKDNHLLG 480
TFDLTGIPPA PRGVPQIEVT FEIDVNGILR VTAEDKGTGN KNKITITNDQ NRLTPEEIER 540
MVNDAEKFAE EDKKLKERID TRNELESYAY SLKNQIGDKE KLGGKLSSED KETMEKAVEE 600
KIEWLESHQD ADIEDFKAKK KELEEIVQPI ISKLYGSAGP PPTGEEDTSE KDEL 654 |
Gene Ontology | GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell. GO:0043231; C:intracellular membrane-bounded organelle; IDA:UniProtKB. GO:0042470; C:melanosome; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0016887; F:ATPase activity; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |