UniProt Accession

 DD19A_MOUSE; Q61655; Q543M2; Q921R0 

Genbank Protein ID

 L25125; AK049467; AK146548; CH466525; BC011270 

Genbank Nucleotide ID

 AAA53629.1; BAC33762.1; BAE27252.1; EDL11480.1; AAH11270.1 

Protein Name

 ATP-dependent RNA helicase DDX19A 

Protein Synonyms/Alias

 DEAD box RNA helicase DEAD5; mDEAD5; DEAD box protein 19A; Eukaryotic translation initiation factor 4A-related sequence 1 

Gene Name

 Ddx19a 

Gene Synonyms/Alias

 Ddx19; Eif4a-rs1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
63	AAQSLLNKLIRSNLV	acetylation	[1]
63	AAQSLLNKLIRSNLV	ubiquitination	[2]
286	SVWKFAQKVVPDPNI	ubiquitination	[2]
343	MIFCHTRKTASWLAA	acetylation	[1]
445	AVNMVDSKHSMNILN	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity). 

Sequence Annotation

 DOMAIN 124 294 Helicase ATP-binding.
 DOMAIN 305 473 Helicase C-terminal.
 NP_BIND 137 144 ATP (By similarity).
 REGION 2 299 N-terminal lobe (By similarity).
 REGION 54 67 N-terminal helix (By similarity).
 REGION 300 478 C-terminal lobe (By similarity).
 MOTIF 91 119 Q motif.
 MOTIF 241 244 DEAD box.
 BINDING 118 118 ATP (By similarity).
 BINDING 428 428 ATP (By similarity).
 BINDING 431 431 ATP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase; Membrane; mRNA transport; Nuclear pore complex; Nucleotide-binding; Nucleus; Protein transport; Reference proteome; RNA-binding; Translocation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 478 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0010043; P:response to zinc ion; IEA:Compara. 

Interpro

 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR014014; RNA_helicase_DEAD_Q_motif. 

Pfam

 PF00270; DEAD
 PF00271; Helicase_C 

SMART

 SM00487; DEXDc
 SM00490; HELICc 

PROSITE

 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 

PRINTS