UniProt Accession

 SRPRB_RAT; Q4FZX7 

Genbank Protein ID

 BC098951 

Genbank Nucleotide ID

 AAH98951.1 

Protein Name

 Signal recognition particle receptor subunit beta 

Protein Synonyms/Alias

 SR-beta 

Gene Name

 Srprb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
197	LIQQQLEKELNTLRV	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity). 

Sequence Annotation

 NP_BIND 69 77 GTP (By similarity).
 NP_BIND 90 93 GTP (By similarity).
 BINDING 118 118 GTP; via amide nitrogen (By similarity).
 BINDING 246 246 GTP; via amide nitrogen (By similarity).  

Keyword

 Complete proteome; Endoplasmic reticulum; GTP-binding; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 269 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0009925; C:basal plasma membrane; IEA:Compara.
 GO:0005905; C:coated pit; IEA:Compara.
 GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0030139; C:endocytic vesicle; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005770; C:late endosome; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0055037; C:recycling endosome; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR024156; Small_GTPase_ARF.
 IPR019009; SRP_receptor_beta_su. 

Pfam

 PF09439; SRPRB 

SMART

  

PROSITE

  

PRINTS