UniProt Accession

 SDSL_HUMAN; Q96GA7 

Genbank Protein ID

 AF134473; BC009849; BC091479 

Genbank Nucleotide ID

 AAP97250.1; AAH09849.1; AAH91479.1 

Protein Name

 Serine dehydratase-like 

Protein Synonyms/Alias

 L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH; Serine dehydratase 2; SDH 2 

Gene Name

 SDSL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
227	PDITSVAKSLGAKTV	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Has low serine dehydratase and threonine dehydratase activity. 

Sequence Annotation

 MOD_RES 48 48 N6-(pyridoxal phosphate)lysine.  

Keyword

 3D-structure; Complete proteome; Lyase; Pyridoxal phosphate; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 329 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0003941; F:L-serine ammonia-lyase activity; IEA:EC.
 GO:0004794; F:L-threonine ammonia-lyase activity; IEA:EC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. 

Interpro

 IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
 IPR001926; Trp_syn_b_sub_like_PLP_eny_SF. 

Pfam

 PF00291; PALP 

SMART

  

PROSITE

 PS00165; DEHYDRATASE_SER_THR 

PRINTS