CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004409
UniProt Accession
Genbank Protein ID
 M24915; M59040; X55150; X56794; X66733; L05423; L05407; L05408; L05409; L05410; L05420; L05421; L05422; M69215; L05423; L05407; L05408; L05410; L05411; L05412; L05414; L05415; L05416; L05417; L05418; L05419; L05420; L05421; L05422; M69215; L05424; L05407; L05408; L05410; L05420; L05421; L05422; M69215; L05424; L05407; L05408; L05410; L05411; L05412; L05414; L05416; L05417; L05418; L05419; L05420; L05421; L05422; M69215; L05424; L05407; L05408; L05410; L05411; L05412; L05414; L05416; L05417; L05418; L05419; L05420; L05421; L05422; M69215; L05424; L05407; L05408; L05410; L05417; L05418; L05420; L05421; L05422; M69215; L05424; L05407; L05408; L05410; L05411; L05412; L05414; L05415; L05416; L05417; L05418; L05419; L05420; L05421; L05422; M69215; AJ251595; S66400; S66400; S66400; AF098641; U40373; AY101192; AY101193; EF581837; FJ216964; AL832642; AL133330; AL136989; AL356215; CH471064; CH471064; CH471064; CH471064; CH471064; BC004372; BC067348; M25078; X55938; S72928; X62739 
Genbank Nucleotide ID
 AAA35674.1; AAA51950.1; CAA38951.1; CAA40133.1; CAA47271.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13624.1; AAB13624.1; AAB13624.1; AAB13624.1; AAB13624.1; AAB13624.1; AAB13624.1; AAB13624.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; CAB61878.1; AAB27917.1; AAB27918.2; AAB27919.1; AAC70782.1; AAA82949.1; AAM50040.1; AAM50041.1; ABQ59315.1; ACI46596.1; CAD89965.1; CAC10347.1; EAW68147.1; EAW68148.1; EAW68149.1; EAW68151.1; EAW68152.1; AAH04372.1; AAH67348.1; AAA36138.1; CAA39404.1; AAB30429.1; CAA44602.1 
Protein Name
 CD44 antigen 
Protein Synonyms/Alias
 CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD44 
Gene Name
 CD44 
Gene Synonyms/Alias
 LHR; MDU2; MDU3; MIC4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
681RRCGQKKKLVINSGNubiquitination[1, 2]
695NGAVEDRKPSGLNGEubiquitination[1]
705GLNGEASKSQEMVHLubiquitination[1, 3]
715EMVHLVNKESSETPDubiquitination[1, 3]
739NLQNVDMKIGV****ubiquitination[1, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
 Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. 
Sequence Annotation
 DOMAIN 32 120 Link.
 REGION 224 649 Stem.
 BINDING 41 41 Hyaluronan (By similarity).
 BINDING 78 78 Hyaluronan (By similarity).
 BINDING 79 79 Hyaluronan (By similarity).
 BINDING 105 105 Hyaluronan (By similarity).
 MOD_RES 21 21 Pyrrolidone carboxylic acid (Probable).
 MOD_RES 672 672 Phosphoserine; by PKC.
 MOD_RES 686 686 Phosphoserine.
 MOD_RES 697 697 Phosphoserine (By similarity).
 MOD_RES 706 706 Phosphoserine.
 CARBOHYD 25 25 N-linked (GlcNAc...) (Potential).
 CARBOHYD 57 57 N-linked (GlcNAc...).
 CARBOHYD 100 100 N-linked (GlcNAc...) (Potential).
 CARBOHYD 110 110 N-linked (GlcNAc...).
 CARBOHYD 120 120 N-linked (GlcNAc...) (Potential).
 CARBOHYD 350 350 N-linked (GlcNAc...) (Potential).
 CARBOHYD 548 548 N-linked (GlcNAc...) (Potential).
 CARBOHYD 599 599 N-linked (GlcNAc...) (Potential).
 CARBOHYD 636 636 N-linked (GlcNAc...) (Potential).
 CARBOHYD 637 637 O-linked (GalNAc...); or Thr-638.
 CARBOHYD 638 638 O-linked (GalNAc...); or Thr-637.
 DISULFID 28 129 By similarity.
 DISULFID 53 118 By similarity.
 DISULFID 77 97 By similarity.  
Keyword
 3D-structure; Alternative splicing; Blood group antigen; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Proteoglycan; Pyrrolidone carboxylic acid; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 742 AA 
Protein Sequence
MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA DLCKAFNSTL 60
PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN NTGVYILTSN TSQYDTYCFN 120
ASAPPEEDCT SVTDLPNAFD GPITITIVNR DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS 180
GSSSERSSTS GGYIFYTFST VHPIPDEDSP WITDSTDRIP ATTLMSTSAT ATETATKRQE 240
TWDWFSWLFL PSESKNHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD 300
EDFISSTIST TPRAFDHTKQ NQDWTQWNPS HSNPEVLLQT TTRMTDVDRN GTTAYEGNWN 360
PEAHPPLIHH EHHEEEETPH STSTIQATPS STTEETATQK EQWFGNRWHE GYRQTPKEDS 420
HSTTGTAAAS AHTSHPMQGR TTPSPEDSSW TDFFNPISHP MGRGHQAGRR MDMDSSHSIT 480
LQPTANPNTG LVEDLDRTGP LSMTTQQSNS QSFSTSHEGL EEDKDHPTTS TLTSSNRNDV 540
TGGRRDPNHS EGSTTLLEGY TSHYPHTKES RTFIPVTSAK TGSFGVTAVT VGDSNSNVNR 600
SLSGDQDTFH PSGGSHTTHG SESDGHSHGS QEGGANTTSG PIRTPQIPEW LIILASLLAL 660
ALILAVCIAV NSRRRCGQKK KLVINSGNGA VEDRKPSGLN GEASKSQEMV HLVNKESSET 720
PDQFMTADET RNLQNVDMKI GV 742 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0005518; F:collagen binding; NAS:UniProtKB.
 GO:0005540; F:hyaluronic acid binding; IDA:UniProtKB.
 GO:0004415; F:hyalurononglucosaminidase activity; IDA:UniProtKB.
 GO:0060442; P:branching involved in prostate gland morphogenesis; IEA:Compara.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Compara.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0051216; P:cartilage development; IEP:UniProtKB.
 GO:0007160; P:cell-matrix adhesion; NAS:UniProtKB.
 GO:0044344; P:cellular response to fibroblast growth factor stimulus; IDA:UniProtKB.
 GO:0030214; P:hyaluronan catabolic process; IDA:UniProtKB.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0070487; P:monocyte aggregation; IMP:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
 GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IDA:BHF-UCL.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IMP:UniProtKB.
 GO:1900625; P:positive regulation of monocyte aggregation; IMP:BHF-UCL.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:BHF-UCL.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:Compara.
 GO:0002246; P:wound healing involved in inflammatory response; IEA:Compara. 
Interpro
 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold.
 IPR001231; CD44_antigen.
 IPR000538; Link. 
Pfam
 PF00193; Xlink 
SMART
 SM00445; LINK 
PROSITE
 PS01241; LINK_1
 PS50963; LINK_2 
PRINTS
 PR00658; CD44.
 PR01265; LINKMODULE.