CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037610
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cysteine and histidine-rich protein 1 
Protein Synonyms/Alias
  
Gene Name
 CYHR1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
100AAAAGSGKLEERLYSubiquitination[1, 2, 3]
146LLADARLKEEQATCPubiquitination[2, 3]
322RNPNLSCKRTLSFQLubiquitination[2]
334FQLLLKSKVTAPLECubiquitination[2, 3, 4, 5]
391CNKLLAAKNINLRLFubiquitination[1, 2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 404 AA 
Protein Sequence
MSGAEEAGGG GPAAGPAGSV PAGVGVGVGA GPGAAAGQAA AAALGEAAGP GLPDEAGLAG 60
ARQLQLQEAA GDPDAPPKKR LRAAEAAEAA AAAAAAGSGK LEERLYSVLC CTVCLDLPKA 120
SVYQCTNGHL MCAGCFIHLL ADARLKEEQA TCPNCRCEIS KSLCCRNLAV EKAVSELPSE 180
CGFCLRQFPR SLLERHQKEE CQDRVTQCKY KRIGCPWHGP FHELTVHEAA CAHPTKTGSE 240
LMEILDGMDQ SHRKEMQLYN SIFSLLSFEK IGYTEVQFRP YRTDDFITRL YYETPRFTVL 300
NQTWVLKARV NDSERNPNLS CKRTLSFQLL LKSKVTAPLE CSFLLLKGPY DDVRISPVIY 360
HFVFTNESNE TDYVPLPIID SVECNKLLAA KNINLRLFLF QIQK 404 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR008974; TRAF-like.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR001293; Znf_TRAF. 
Pfam
  
SMART
 SM00184; RING 
PROSITE
 PS50089; ZF_RING_2
 PS50145; ZF_TRAF 
PRINTS