CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042897
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cullin-associated NEDD8-dissociated protein 1 
Protein Synonyms/Alias
  
Gene Name
 CAND1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
137RIGEYLEKIIPLVVKubiquitination[1, 2, 3, 4]
237KVRRAAAKCLDAVVSubiquitination[4, 5]
255EMLPEFYKTVSPALIubiquitination[2, 5]
285HAYLSLLKQTRPVQSubiquitination[2]
Reference
 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 442 AA 
Protein Sequence
LIHAGSALAA NVCKKITGRL TSAIAKQEDV SVQLEALDIM ADMLSRQGGL LVNFHPSILT 60
CLLPQLTSPR LAVRKRTIIA LGHLVMSCGN IVFVDLIEHL LSELSKNDSM STTRTYIQCI 120
AAISRQAGHR IGEYLEKIIP LVVKFCNVDD DELREYCIQA FESFVRRCPK EVYPHVSTII 180
NICLKYLTYD PNYNYDDEDE DENAMDADGG DDDDQGSDDE YSDDDDMSWK VRRAAAKCLD 240
AVVSTRHEML PEFYKTVSPA LISRFKEREE NVKADVFHAY LSLLKQTRPV QSWLCDPDAM 300
EQGETPLTML QSQVPNIVKA LHKQMKEKSV KTRQCCFNML TELVNVLPGA LTQHIPVLVP 360
GIIFSLNDKS SSSNLKIDAL SCLYVILCNH SPQVFHPHVQ ALVPPVVACV GDPFYKITSE 420
ALLVTQQLVK AHHMPEAQWL RL 442 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold. 
Pfam
  
SMART
  
PROSITE
  
PRINTS