UniProt Accession

 PDIA6_HUMAN; Q15084; Q53RC7; Q6ZSH5; Q99778 

Genbank Protein ID

 D49489; AK127433; AK289428; AC092687; CH471053; BC001312; U79278 

Genbank Nucleotide ID

 BAA08450.1; BAC86977.1; BAF82117.1; AAY24070.1; EAX00950.1; AAH01312.1; AAB50217.1 

Protein Name

 Protein disulfide-isomerase A6 

Protein Synonyms/Alias

 Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7 

Gene Name

 PDIA6 

Gene Synonyms/Alias

 ERP5; P5; TXNDC7 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
77	TALKDVVKVGAVDAD	ubiquitination	[1]
160	RSDSSSKKDVIELTD	ubiquitination	[2]
241	IRGFPTIKIFQKGES	ubiquitination	[2]
245	PTIKIFQKGESPVDY	ubiquitination	[1, 2]
368	AINARKMKFALLKGS	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. 

Sequence Annotation

 DOMAIN 20 133 Thioredoxin 1.
 DOMAIN 154 287 Thioredoxin 2.
 MOTIF 437 440 Prevents secretion from ER (Potential).
 ACT_SITE 55 55 Nucleophile (By similarity).
 ACT_SITE 58 58 Nucleophile (By similarity).
 ACT_SITE 190 190 Nucleophile (By similarity).
 ACT_SITE 193 193 Nucleophile (By similarity).
 MOD_RES 428 428 Phosphoserine.
 DISULFID 55 58 Redox-active (By similarity).
 DISULFID 190 193 Redox-active (By similarity).  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Chaperone; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Isomerase; Membrane; Phosphoprotein; Polymorphism; Redox-active center; Reference proteome; Repeat; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 440 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0003756; F:protein disulfide isomerase activity; TAS:ProtInc.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro. 

Interpro

 IPR005788; Disulphide_isomerase.
 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS00014; ER_TARGET
 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS

 PR00421; THIOREDOXIN.