CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007652
UniProt Accession
Genbank Protein ID
 U12428 
Genbank Nucleotide ID
Protein Name
 Early growth response protein 3 
Protein Synonyms/Alias
 EGR-3 
Gene Name
 Egr3 
Gene Synonyms/Alias
 Egr-3 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
4****MTGKLAEKLPVacetylation[1]
254PQPPLTLKPIRPRKYacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Probable transcription factor involved in muscle spindle development (By similarity). 
Sequence Annotation
 ZN_FING 275 299 C2H2-type 1.
 ZN_FING 305 327 C2H2-type 2.
 ZN_FING 333 355 C2H2-type 3.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 387 AA 
Protein Sequence
MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVAHYTQMA TENVMDIGLT 60
NEKPNPELSY SGSFQPAPGN KTVTYLGKFA FDSPSNWCQD NIISLMSAGI LGVPPASGAL 120
STQTTTASMV QPPQGDVEAM YPALPPYSNC GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK 180
PALDSNLFPM IPDYNLYHHP NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH 240
PGFGSLPQPP LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT 300
GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR HAKIHLKQKE 360
KKSEKGGAPS ASSAPTVSLA PVVTTCA 387 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Compara.
 GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Compara.
 GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IEA:Compara.
 GO:0035767; P:endothelial cell chemotaxis; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0007274; P:neuromuscular synaptic transmission; IEA:Compara.
 GO:0007422; P:peripheral nervous system development; IEA:Compara.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR021849; DUF3446.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF11928; DUF3446 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS