CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028893
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone-lysine N-methyltransferase EHMT2 
Protein Synonyms/Alias
  
Gene Name
 Ehmt2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1066LQLYRTAKMGWGVRAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Chromosome; Complete proteome; Methyltransferase; Nucleus; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1229 AA 
Protein Sequence
MRGLPRGRGL MRARGRGRAA PTGGRGRGRG GAHRGRGRPR SLLSLPRAQA SWAPQLPAGL 60
TGPPVPCLPS QGEAPAEMGA LLLEKEPRGA AERVHSSLGD TPQSEETLPK ANPDSLEPAG 120
PSSPASVTVT VGDEGADTPV GAASLIGDEP ESLEGDGGRI VLGHATKSFP SSPSKGGACP 180
SRAKMSMTGA GKSPPSVQSL AMRLLSMPGA QGAATAGPEP SPATTAAQEG QPKVHRARKT 240
MSKPSNGQPP IPEKRPPEVQ HFRMSDDMHL GKVTSDVAKR RKLNSGSLSE DLGSAGGSGD 300
IILEKGEPRP LEEWETVVGD DFSLYYDAYS VDERVDSDSK SEVEALAEQL SEEEEEEEEE 360
EEEEEEEEEE EEEEEEDEES GNQSDRSGSS GRRKAKKKWR KDSPWVKPSR KRRKREPPRA 420
KEPRGVSNDT SSLETERGFE ELPLCSCRME APKIDRISER AGHKCMATES VDGELLGCNA 480
AILKRETMRP SSRVALMVLC EAHRARMVKH HCCPGCGYFC TAGTFLECHP DFRVAHRFHK 540
ACVSQLNGMV FCPHCGEDAS EAQEVTIPRG DGGTPPIGTA APALPPLAHD APGRADTSQP 600
SARMRGHGEP RRPPCDPLAD TIDSSGPSLT LPNGGCLSAV GLPPGPGREA LEKALVIQES 660
ERRKKLRFHP RQLYLSVKQG ELQKVILMLL DNLDPNFQSD QQSKRTPLHA AAQKGSVEIC 720
HVLLQAGANI NAVDKQQRTP LMEAVVNNHL EVARYMVQLG GCVYSKEEDG STCLHHAAKI 780
GNLEMVSLLL STGQVDVNAQ DSGGWTPIIW AAEHKHIDVI RMLLTRGADV TLTDNEENIC 840
LHWASFTGSA AIAEVLLNAQ CDLHAVNYHG DTPLHIAARE SYHDCVLLFL SRGANPELRN 900
KEGDTAWDLT PERSDVWFAL QLNRKLRLGV GNRAVRTEKI ICRDVARGYE NVPIPCVNGV 960
DGEPCPEDYK YISENCETST MNIDRNITHL QHCTCVDDCS SSNCLCGQLS IRCWYDKDGR 1020
LLQEFNKIEP PLIFECNQAC SCWRSCKNRV VQSGIKVRLQ LYRTAKMGWG VRALQTIPQG 1080
TFICEYVGEL ISDAEADVRE DDSYLFDLDN KDGEVYCIDA RYYGNISRFI NHLCDPNIIP 1140
VRVFMLHQDL RFPRIAFFSS RDIRTGEELG FDYGDRFWDI KSKYFTCQCG SEKCKHSAEA 1200
IALEQSRLAR LDPHPELLPD LSSLPPINT 1229 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0010424; P:DNA methylation on cytosine within a CG sequence; IMP:MGI.
 GO:0009566; P:fertilization; IMP:MGI.
 GO:0070734; P:histone H3-K27 methylation; IMP:MGI.
 GO:0051567; P:histone H3-K9 methylation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0035265; P:organ growth; IMP:MGI.
 GO:0007286; P:spermatid development; IMP:MGI.
 GO:0007130; P:synaptonemal complex assembly; IMP:MGI. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR003616; Post-SET_dom.
 IPR007728; Pre-SET_dom.
 IPR003606; Pre-SET_Zn-bd_sub.
 IPR001214; SET_dom. 
Pfam
 PF12796; Ank_2
 PF05033; Pre-SET
 PF00856; SET 
SMART
 SM00248; ANK
 SM00508; PostSET
 SM00468; PreSET
 SM00317; SET 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50867; PRE_SET
 PS50280; SET 
PRINTS
 PR01415; ANKYRIN.