CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024081
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SH3 domain-binding protein 5 
Protein Synonyms/Alias
 SH3BP-5; SH3 domain-binding protein that preferentially associates with BTK 
Gene Name
 Sh3bp5 
Gene Synonyms/Alias
 Sab 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
136TEVLRAAKETISLAEubiquitination[1]
251GEYKAALKSLERISDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. 
Sequence Annotation
 MOD_RES 354 354 Phosphoserine; by MAPK12 and MAPK9 (By
 MOD_RES 421 421 Phosphoserine.
 MOD_RES 424 424 Phosphoserine; by MAPK12 (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Mitochondrion; Phosphoprotein; Reference proteome; SH3-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 463 AA 
Protein Sequence
MDTALKRSRS DEPAELPPPA REVEEKEEEE ERMEQGLEEE EEEVDPRIQG ELEKLNQSTD 60
DINRRETELE DARQKFRSVL VEATVKLDEL AKKIGKAVED SKPYWEARRV ARQAQLEAQK 120
ATQDFQRATE VLRAAKETIS LAEQRLLEDD KRQFDSAWQE MLNHATQRVM EAEQTKTRSE 180
LVHKETAARY NAAMGRMRQL EKKLKRAINK SKPYFELKAK YYVQLEQLKK TVDDLQAKLA 240
LAKGEYKAAL KSLERISDEI HERRRSNAMG PRGCGVGAEG SIASVENLPV SKPEPDAISV 300
ASEAFEDDNC SNLVSEDDSE TQSVSSFSSG PTSPSEMPDQ FPAVARPGSL DLPSPVSLSE 360
FGMMFPILGP RSECSGASSP ECEVERGDRA EGAENKMSDK ANNNRVLGST NGGSGRSRSQ 420
SSTSLESQAL ETRMKQLSLQ CSKGRDGIIA DIKMIFIFYT FLQ 463 
Gene Ontology
 GO:0005737; C:cytoplasm; IC:MGI.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0004860; F:protein kinase inhibitor activity; ISO:MGI.
 GO:0017124; F:SH3 domain binding; TAS:UniProtKB.
 GO:0035556; P:intracellular signal transduction; ISO:MGI. 
Interpro
 IPR007940; SH3-bd_5. 
Pfam
 PF05276; SH3BP5 
SMART
  
PROSITE
  
PRINTS