UniProt Accession

 ARP19_HUMAN; P56211; B2R497; Q6IAM2; Q86TA6; Q9UD70 

Genbank Protein ID

 AJ223091; AF084555; CR457132; AL833077; AK311751; AC025917; CH471082; BC003418; BC100015 

Genbank Nucleotide ID

 CAA11115.1; AAD52044.1; CAG33413.1; CAD89929.1; BAG34694.1; EAW77454.1; AAH03418.1; AAI00016.1 

Protein Name

 cAMP-regulated phosphoprotein 19 

Protein Synonyms/Alias

 ARPP-19 

Gene Name

 ARPP19 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
26	DKVTSPEKAEEAKLK	acetylation	[1]
58	KRLQKGQKYFDSGDY	ubiquitination	[2]
109	KPSLVASKLAG****	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 62 62 Phosphoserine; by GWL (Probable).
 MOD_RES 104 104 Phosphoserine; by PKA (By similarity).
 MOD_RES 109 109 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Mitosis; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 112 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0019212; F:phosphatase inhibitor activity; ISS:UniProtKB.
 GO:0015459; F:potassium channel regulator activity; IDA:UniProtKB.
 GO:0051721; F:protein phosphatase 2A binding; ISS:UniProtKB.
 GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
 GO:0008601; F:protein phosphatase type 2A regulator activity; ISS:UniProtKB.
 GO:0005102; F:receptor binding; IDA:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:UniProtKB.
 GO:0007067; P:mitosis; IMP:UniProtKB.
 GO:0045722; P:positive regulation of gluconeogenesis; IDA:UniProtKB.
 GO:0046326; P:positive regulation of glucose import; NAS:UniProtKB. 

Interpro

 IPR006760; Endosulphine. 

Pfam

 PF04667; Endosulfine 

SMART

  

PROSITE

  

PRINTS