CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013141
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho guanine nucleotide exchange factor 40 
Protein Synonyms/Alias
 Protein SOLO 
Gene Name
 Arhgef40 
Gene Synonyms/Alias
 Solo 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
189VCPRFVHKEGLMVGHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 May act as a guanine nucleotide exchange factor (GEF) (By similarity). 
Sequence Annotation
 DOMAIN 1083 1251 DH.
 DOMAIN 1263 1370 PH.
 MOD_RES 262 262 Phosphoserine (By similarity).
 MOD_RES 1080 1080 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1517 AA 
Protein Sequence
MEPEPVEDCV QSTLAALYPP FEATAPTLLG QVFQVVERTY QEDALRYTLD FLVPAKHLLA 60
KVQQEACAQY SGFLFFHEGW PLCLHEQVVV QLAALPWQLL RPGDFYLQVV PSAAQAPRLA 120
LKCLAPGGGR VQELPVPSEA CAYLFTPEWL QGINKDRPTG RLSTCLLSAP SGIQRLPWAE 180
LVCPRFVHKE GLMVGHQPST LPPELPSGPP GLPSSPLPEE VLGTRSPGDG HNAPAEGPEG 240
EYVELLEVTL PVRGSPVDAE ASGLSRTRTV PARKSTGGKG RHRRHRAWMN QKGLGSRDQD 300
GTRPPGEGSS TGASSDSPSG AEADPDATAL QASEPPAEAL GEAPESCLLS GEAVGGVGQG 360
AEGPPGTPRR TGKGNRRKKR AAGRGAGSRG GEGTSLSPRD KEETRQQEVL VSLPSPSEQE 420
PAECSLVKEK EDSGKQESES KEELKPADEK EPARPEDYEP PEEEIRESEK EELTPQCTAG 480
STGPEWFPSE PSTQPLETVQ NVKGDSLPEE TPPVSVLDDP VVAWDLMASG FFVLTGGVDQ 540
TGRALLTITP PPPCLPEESS PSQETLSTAL RYLHSLLRPD LQLLGLTILL DLRKAPPLPP 600
ALLPALSQLQ DSGEPPLIQR LVILIHEDPP AELCGFQGAE LLSEKDLKRV AKPEELQWDL 660
GGHRDLSPNH WAEIHQEVAR LCTLCQGVLT SVRQAIEELE GTAEPKEEEA VGMPEPLQKV 720
LADPRLTALQ RNGGAILMRL RSAHSSKLEG PGPAELYQEV DEAIHQLVRL SNLRVQQQEE 780
RQRLRQVQQV LQWLSGPGEE QLASFSMPGN SLSVLQETEL RFRAFSTEVQ ERLVQAREAL 840
ALEEDLTSQK VLDIFEQRLE QAESGLHRAL RLQRFFQQAH EWVDEGSARL AGAGSGREAL 900
LAALALRRAP EPSAGTFQEM RALALDLGSP AALREWGRCR ARCQELERRI QQQLGEEASP 960
RSHRRRRADS ASSAGAQHGA HSPSPSLSSL LLPSSPGPRA APSHCSLTPC GEDYEEEGLE 1020
LAPETDGRPP RAVLIRGLEV TSTEVVDRTC SPREHVLLGR AGGPDGPWGI GTPRMERKRS 1080
ISAQQRLVSE LIACEQEYVT TLNEPVPLPG PELTPELRCT WAAALSVRER LRSFHGTHFL 1140
QELQGCAAHP LRIGACFLRH GDQFNLYAQF VKHRHKLESG LAALTPSVKG SMESSPCLPR 1200
ALQQPLEQLA RYGQLLEELL REAGPELSSE RQALRAAVQL LQEQEARGRD LLAVEAVRGC 1260
EIDLKEQGQL LHRDPFTVIC GRKKCLRHVF LFEDLLLFSK LKGSEGGSET FVYKQAFKTA 1320
DMGLTENIGD SGLCFELWFR RRRAREAYTL QATSPETKLK WTSSIAQLLW RQAAHNKELR 1380
VQQMVSMGIG NKPFLDIKAL GERTLSALLT GRAARTRASV AVSSFEHAGP SLPGLSPGAC 1440
SLPARVEEEA WDLDVKQISL ASETLDSSGD VSPGPRNSPS LQPPSPGSST PALTSGGILG 1500
LSRQSHSRAL SDPTTPL 1517 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF00621; RhoGEF 
SMART
 SM00233; PH 
PROSITE
 PS00741; DH_1
 PS50010; DH_2
 PS50003; PH_DOMAIN 
PRINTS