UniProt Accession

 SNX12_HUMAN; Q9UMY4; F8W8K5; Q8WUG9 

Genbank Protein ID

 AF171229; BT007203; AL590764; BC020559 

Genbank Nucleotide ID

 AAD48491.1; AAP35867.1 

Protein Name

 Sorting nexin-12 

Protein Synonyms/Alias

  

Gene Name

 SNX12 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
62	RTNLPIFKLKESCVR	ubiquitination	[1, 2, 3]
79	YSDFEWLKNELERDS	ubiquitination	[3]
87	NELERDSKIVVPPLP	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May be involved in several stages of intracellular trafficking (By similarity). 

Sequence Annotation

 DOMAIN 28 152 PX.
 BINDING 71 71 Phosphatidylinositol 3-phosphate (By
 BINDING 73 73 Phosphatidylinositol 3-phosphate; via
 BINDING 96 96 Phosphatidylinositol 3-phosphate (By
 BINDING 119 119 Phosphatidylinositol 3-phosphate (By
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 23 23 Phosphotyrosine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Lipid-binding; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 172 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR001683; Phox. 

Pfam

 PF00787; PX 

SMART

 SM00312; PX 

PROSITE

 PS50195; PX 

PRINTS