CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021323
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cell death-inducing p53-target protein 1 
Protein Synonyms/Alias
 Cell death involved p53-target; Cell death-inducing protein; LITAF-like protein; Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein; Transmembrane protein I1 
Gene Name
 CDIP1 
Gene Synonyms/Alias
 C16orf5; CDIP; LITAFL 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21TAPLLEEKSGAPPTPubiquitination[1, 2, 3]
198THTCPSCKAYIYTYKubiquitination[2, 3, 4, 5]
205KAYIYTYKRLC****ubiquitination[2, 3, 4, 5]
Reference
 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
 Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner. 
Sequence Annotation
  
Keyword
 Alternative splicing; Apoptosis; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 208 AA 
Protein Sequence
MSSEPPPPYP GGPTAPLLEE KSGAPPTPGR SSPAVMQPPP GMPLPPADIG PPPYEPPGHP 60
MPQPGFIPPH MSADGTYMPP GFYPPPGPHP PMGYYPPGPY TPGPYPGPGG HTATVLVPSG 120
AATTVTVLQG EIFEGAPVQT VCPHCQQAIT TKISYEIGLM NFVLGFFCCF MGCDLGCCLI 180
PCLINDFKDV THTCPSCKAY IYTYKRLC 208 
Gene Ontology
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0006917; P:induction of apoptosis; IDA:MGI.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IMP:MGI.
 GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IGI:MGI. 
Interpro
 IPR006629; LITAF. 
Pfam
 PF10601; zf-LITAF-like 
SMART
 SM00714; LITAF 
PROSITE
  
PRINTS