UniProt Accession

 CLC2D_MOUSE; Q91V08; Q1AFZ3; Q8VI19; Q8VI20 

Genbank Protein ID

 AF350409; AF320598; AF320599; AF321553; AY137338; AY320031; BC106776; DQ143111 

Genbank Nucleotide ID

 AAK70357.1; AAL37198.1; AAL37199.1; AAK50881.1; AAN15947.1; AAQ16529.1; AAI06777.1; ABA43361.1 

Protein Name

 C-type lectin domain family 2 member D 

Protein Synonyms/Alias

 C-type lectin-related protein B; Clr-b; Lectin-like transmembrane protein; Osteoclast inhibitory lectin 

Gene Name

 Clec2d 

Gene Synonyms/Alias

 Clrb; Ocil 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	PQEVEVGKILQGKRH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Binds high molecular weight sulfated glycosaminoglycans. 

Sequence Annotation

 DOMAIN 87 202 C-type lectin.
 CARBOHYD 100 100 N-linked (GlcNAc...) (Potential).
 DISULFID 80 91 By similarity.  

Keyword

 Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Lectin; Membrane; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 207 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; TAS:MGI.
 GO:0030246; F:carbohydrate binding; ISS:MGI.
 GO:0046703; F:natural killer cell lectin-like receptor binding; IDA:MGI.
 GO:0004888; F:transmembrane signaling receptor activity; ISS:MGI.
 GO:0006968; P:cellular defense response; TAS:MGI.
 GO:0045671; P:negative regulation of osteoclast differentiation; IDA:MGI.
 GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IDA:MGI. 

Interpro

 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold. 

Pfam

 PF00059; Lectin_C 

SMART

 SM00034; CLECT 

PROSITE

 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2 

PRINTS