CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004146
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Intercellular adhesion molecule 1 
Protein Synonyms/Alias
 ICAM-1; MALA-2; MyD10; CD54 
Gene Name
 Icam1 
Gene Synonyms/Alias
 Icam-1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
529KAQEEAIKLKGQAPPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). 
Sequence Annotation
 DOMAIN 41 102 Ig-like C2-type 1.
 DOMAIN 127 195 Ig-like C2-type 2.
 DOMAIN 232 299 Ig-like C2-type 3.
 DOMAIN 327 381 Ig-like C2-type 4.
 DOMAIN 415 468 Ig-like C2-type 5.
 MOTIF 151 153 Cell attachment site; atypical
 MOTIF 179 181 Cell attachment site (Potential).
 CARBOHYD 47 47 N-linked (GlcNAc...).
 CARBOHYD 185 185 N-linked (GlcNAc...).
 CARBOHYD 204 204 N-linked (GlcNAc...).
 CARBOHYD 267 267 N-linked (GlcNAc...).
 CARBOHYD 311 311 N-linked (GlcNAc...).
 CARBOHYD 362 362 N-linked (GlcNAc...).
 CARBOHYD 388 388 N-linked (GlcNAc...).
 CARBOHYD 409 409 N-linked (GlcNAc...).
 CARBOHYD 456 456 N-linked (GlcNAc...).
 CARBOHYD 469 469 N-linked (GlcNAc...).
 DISULFID 48 91 By similarity.
 DISULFID 52 95 By similarity.
 DISULFID 134 188 By similarity.
 DISULFID 239 292 By similarity.
 DISULFID 334 374 By similarity.
 DISULFID 422 461 By similarity.  
Keyword
 Alternative splicing; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 537 AA 
Protein Sequence
MASTRAKPTL PLLLALVTVV IPGPGDAQVS IHPREAFLPQ GGSVQVNCSS SCKEDLSLGL 60
ETQWLKDELE SGPNWKLFEL SEIGEDSSPL CFENCGTVQS SASATITVYS FPESVELRPL 120
PAWQQVGKDL TLRCHVDGGA PRTQLSAVLL RGEEILSRQP VGGHPKDPKE ITFTVLASRG 180
DHGANFSCRT ELDLRPQGLA LFSNVSEARS LRTFDLPATI PKLDTPDLLE VGTQQKLFCS 240
LEGLFPASEA RIYLELGGQM PTQESTNSSD SVSATALVEV TEEFDRTLPL RCVLELADQI 300
LETQRTLTVY NFSAPVLTLS QLEVSEGSQV TVKCEAHSGS KVVLLSGVEP RPPTPQVQFT 360
LNASSEDHKR SFFCSAALEV AGKFLFKNQT LELHVLYGPR LDETDCLGNW TWQEGSQQTL 420
KCQAWGNPSP KMTCRRKADG ALLPIGVVKS VKQEMNGTYV CHAFSSHGNV TRNVYLTVLY 480
HSQNNWTIII LVPVLLVIVG LVMAASYVYN RQRKIRIYKL QKAQEEAIKL KGQAPPP 537 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0001772; C:immunological synapse; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0051856; P:adhesion to symbiont; IEA:Compara.
 GO:0033627; P:cell adhesion mediated by integrin; IDA:MGI.
 GO:0007569; P:cell aging; IEA:Compara.
 GO:0071312; P:cellular response to alkaloid; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IDA:MGI.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0071347; P:cellular response to interleukin-1; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0031669; P:cellular response to nutrient levels; IEA:Compara.
 GO:0071356; P:cellular response to tumor necrosis factor; IEA:Compara.
 GO:0007159; P:leukocyte cell-cell adhesion; IMP:MGI.
 GO:0050900; P:leukocyte migration; IEA:Compara.
 GO:0022614; P:membrane to membrane docking; IEA:Compara.
 GO:0051926; P:negative regulation of calcium ion transport; IEA:Compara.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0002693; P:positive regulation of cellular extravasation; IEA:Compara.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Compara.
 GO:0045907; P:positive regulation of vasoconstriction; IEA:Compara.
 GO:0030155; P:regulation of cell adhesion; IDA:MGI.
 GO:0008360; P:regulation of cell shape; IEA:Compara.
 GO:0043200; P:response to amino acid stimulus; IEA:Compara.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0046688; P:response to copper ion; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0034698; P:response to gonadotropin stimulus; IEA:Compara.
 GO:0010212; P:response to ionizing radiation; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0010477; P:response to sulfur dioxide; IEA:Compara.
 GO:0002291; P:T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; IEA:Compara.
 GO:0002457; P:T cell antigen processing and presentation; IDA:MGI.
 GO:0046813; P:virion attachment, binding of host cell surface receptor; IEA:Compara. 
Interpro
 IPR003988; ICAM.
 IPR013768; ICAM_N.
 IPR003987; ICAM_VCAM_N.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub. 
Pfam
 PF03921; ICAM_N 
SMART
 SM00409; IG 
PROSITE
 PS50835; IG_LIKE 
PRINTS
 PR01473; ICAM.
 PR01472; ICAMVCAM1.