CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019361
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kin of IRRE-like protein 1 
Protein Synonyms/Alias
 Kin of irregular chiasm-like protein 1; Nephrin-like protein 1 
Gene Name
 KIRREL 
Gene Synonyms/Alias
 KIRREL1; NEPH1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
585STATRVMKAIYSSFKubiquitination[1, 2]
592KAIYSSFKDDVDLKQubiquitination[1]
598FKDDVDLKQDLRCDTubiquitination[2]
615TREEYEMKDPTNGYYubiquitination[1, 2]
745EAYDPIGKYATATRFubiquitination[1, 2, 3, 4]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). 
Sequence Annotation
 DOMAIN 21 115 Ig-like C2-type 1.
 DOMAIN 120 216 Ig-like C2-type 2.
 DOMAIN 223 299 Ig-like C2-type 3.
 DOMAIN 308 387 Ig-like C2-type 4.
 DOMAIN 392 488 Ig-like C2-type 5.
 MOTIF 405 407 Cell attachment site (Potential).
 MOD_RES 605 605 Phosphotyrosine; by FYN (By similarity).
 MOD_RES 606 606 Phosphotyrosine; by FYN (By similarity).
 MOD_RES 622 622 Phosphotyrosine.
 MOD_RES 625 625 Phosphotyrosine.
 MOD_RES 724 724 Phosphotyrosine.
 CARBOHYD 46 46 N-linked (GlcNAc...) (Potential).
 CARBOHYD 140 140 N-linked (GlcNAc...) (Potential).
 CARBOHYD 297 297 N-linked (GlcNAc...).
 CARBOHYD 471 471 N-linked (GlcNAc...) (Potential).
 DISULFID 42 100 By similarity.
 DISULFID 143 200 By similarity.
 DISULFID 244 287 By similarity.
 DISULFID 329 371 By similarity.
 DISULFID 413 472 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 757 AA 
Protein Sequence
MLSLLVWILT LSDTFSQGTQ TRFSQEPADQ TVVAGQRAVL PCVLLNYSGI VQWTKDGLAL 60
GMGQGLKAWP RYRVVGSADA GQYNLEITDA ELSDDASYEC QATEAALRSR RAKLTVLIPP 120
EDTRIDGGPV ILLQAGTPHN LTCRAFNAKP AATIIWFRDG TQQEGAVAST ELLKDGKRET 180
TVSQLLINPT DLDIGRVFTC RSMNEAIPSG KETSIELDVH HPPTVTLSIE PQTVQEGERV 240
VFTCQATANP EILGYRWAKG GFLIEDAHES RYETNVDYSF FTEPVSCEVH NKVGSTNVST 300
LVNVHFAPRI VVDPKPTTTD IGSDVTLTCV WVGNPPLTLT WTKKDSNMGP RPPGSPPEAA 360
LSAQVLSNSN QLLLKSVTQA DAGTYTCRAI VPRIGVAERE VPLYVNGPPI ISSEAVQYAV 420
RGDGGKVECF IGSTPPPDRI AWAWKENFLE VGTLERYTVE RTNSGSGVLS TLTINNVMEA 480
DFQTHYNCTA WNSFGPGTAI IQLEEREVLP VGIIAGATIG ASILLIFFFI ALVFFLYRRR 540
KGSRKDVTLR KLDIKVETVN REPLTMHSDR EDDTASVSTA TRVMKAIYSS FKDDVDLKQD 600
LRCDTIDTRE EYEMKDPTNG YYNVRAHEDR PSSRAVLYAD YRAPGPARFD GRPSSRLSHS 660
SGYAQLNTYS RGPASDYGPE PTPPGPAAPA GTDTTSQLSY ENYEKFNSHP FPGAAGYPTY 720
RLGYPQAPPS GLERTPYEAY DPIGKYATAT RFSYTSQHSD YGQRFQQRMQ THV 773 
Gene Ontology
 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0043198; C:dendritic shaft; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0016337; P:cell-cell adhesion; IEA:Compara.
 GO:0007588; P:excretion; IEA:Compara.
 GO:0001933; P:negative regulation of protein phosphorylation; IEA:Compara.
 GO:0030838; P:positive regulation of actin filament polymerization; IEA:Compara. 
Interpro
 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 
Pfam
 PF08205; C2-set_2
 PF07679; I-set 
SMART
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS