UniProt Accession

 STAU2_HUMAN; Q9NUL3; B7Z1I6; B7Z292; B7Z8B4; E7ER74; E9PEI3; E9PF26; E9PF50; Q6AHY7; Q96HM0; Q96HM1; Q9NVI5; Q9UGG6 

Genbank Protein ID

 Y19062; AF459097; AF459098; AK001576; AK002152; AK023314; AK293496; AK294466; AK303104; CR627442; AC018620; AC027018; AC100784; BC008369; BC008370 

Genbank Nucleotide ID

 CAB64341.1; AAN37926.1; AAN37927.1; BAA91766.1; BAA92111.1; BAB14522.1; BAH11522.1; BAH11778.1; BAH13900.1; CAH10527.1; AAH08369.1; AAH08370.1 

Protein Name

 Double-stranded RNA-binding protein Staufen homolog 2 

Protein Synonyms/Alias

  

Gene Name

 STAU2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
74	ELNGLAMKRGEPAIY	ubiquitination	[1]
142	ARHNAAMKALQALQN	ubiquitination	[1]
225	AEGEGNSKKLSKKRA	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 RNA-binding protein required for the microtubule- dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). 

Sequence Annotation

 DOMAIN 8 75 DRBM 1.
 DOMAIN 95 181 DRBM 2.
 DOMAIN 207 274 DRBM 3.
 DOMAIN 307 375 DRBM 4.
 REGION 381 570 Required for dendritic transport (By
 MOTIF 273 291 Nuclear localization signal 1 (By
 MOTIF 373 412 Nuclear localization signal 2 (By
 MOD_RES 188 188 Phosphoserine.
 MOD_RES 395 395 Phosphoserine.
 MOD_RES 405 405 Phosphothreonine.
 MOD_RES 416 416 Phosphoserine.
 MOD_RES 426 426 Phosphoserine.
 MOD_RES 440 440 Phosphoserine.
 MOD_RES 455 455 Phosphoserine.
 MOD_RES 492 492 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Endoplasmic reticulum; Microtubule; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 570 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0003725; F:double-stranded RNA binding; TAS:ProtInc.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR001159; Ds-RNA-bd.
 IPR014720; dsRNA-bd-like_dom. 

Pfam

 PF00035; dsrm 

SMART

 SM00358; DSRM 

PROSITE

 PS50137; DS_RBD 

PRINTS