| Tag | Content |
|---|
| CPLM ID | CPLM-018217 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ankyrin repeat and SOCS box protein 15 |
Protein Synonyms/Alias | ASB-15 |
Gene Name | Asb15 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 133 | NVKTLLDKGVWPNTK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). |
Sequence Annotation | REPEAT 75 104 ANK 1.
REPEAT 110 139 ANK 2.
REPEAT 143 172 ANK 3.
REPEAT 176 205 ANK 4.
REPEAT 209 238 ANK 5.
REPEAT 242 271 ANK 6.
REPEAT 275 304 ANK 7.
REPEAT 307 336 ANK 8.
REPEAT 349 378 ANK 9.
REPEAT 379 408 ANK 10.
REPEAT 416 444 ANK 11.
DOMAIN 524 579 SOCS box. |
Keyword | ANK repeat; Complete proteome; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 583 AA |
Protein Sequence | MDINDDSNDD HLASYDIQLC IQESIEASQA IFHPKRLVQL SDQNRKLVEA IRQGRIFELQ 60
EYVQYKYALE EADEKGWFPL HEAVVQPIQQ ILETVLDASY KTLWEFKTCD GETPLTLAVK 120
AGLVENVKTL LDKGVWPNTK NDKGETPLLI AIKRGSYDMV SALIKYNTSL DQPCVKRWSA 180
MHEAAKQGRK DIITLLLNHR GNVHLRDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVFALA 240
DDGASVLFEA AGGGNPDCIS LLLKYGGSGN VPNRAGHLPI HRAAYEGHYL ALKYLIPVTS 300
KHAIQKSGLT PIHSAAEGQN AQCLELLIEN GFDVNALLAD HISQSYDDER KTALYFAVSN 360
NDIHCTEVLL AAGADPNLDP LNCLLVAVRA NRHEIVRLLL SYGANVNCYF MHVNDTRFPS 420
AIQYALNDEI MLRLLLNNGY QVELCFDCMH GNIFGNSFVW SETEEEGLPG WTSCIIKDNP 480
FCEFITVPWM KHLVGGIVRI LIDYMDYVPL CAKLKSVLEV QREWPEIRQI IENPCSLKHL 540
CRLKIRRVMG LQRLCQPASI QMLPLPAAMR RYLLFKEFDL YGQ 583 |
Gene Ontology | GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |