| Tag | Content |
|---|
| CPLM ID | CPLM-007385 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Peroxiredoxin DOT5 |
Protein Synonyms/Alias | Disrupter of telomere silencing protein 5; Nuclear thiol peroxidase; nTPx; Thioredoxin reductase |
Gene Name | DOT5 |
Gene Synonyms/Alias | YIL010W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 24 | MLEEEESKLAPISTP | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Has a role in telomere silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. Also has a role in the regulation of telomere length. Acts as an alkyl-hydroperoxide reductase in the nucleus during post-diauxic growth. Preferentially reduces alkyl-hydroperoxides rather than hydrogen preoxide. Acts as an antioxidant necessary for stationary phase survival. |
Sequence Annotation | DOMAIN 63 211 Thioredoxin.
ACT_SITE 107 107 Cysteine sulfenic acid (-SOH)
DISULFID 107 112 Redox-active. |
Keyword | 3D-structure; Antioxidant; Chromosome; Complete proteome; Disulfide bond; Nucleus; Oxidoreductase; Peroxidase; Redox-active center; Reference proteome; Telomere; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 215 AA |
Protein Sequence | MGEALRRSTR IAISKRMLEE EESKLAPIST PEVPKKKIKT GPKHNANQAV VQEANRSSDV 60
NELEIGDPIP DLSLLNEDND SISLKKITEN NRVVVFFVYP RASTPGCTRQ ACGFRDNYQE 120
LKKYAAVFGL SADSVTSQKK FQSKQNLPYH LLSDPKREFI GLLGAKKTPL SGSIRSHFIF 180
VDGKLKFKRV KISPEVSVND AKKEVLEVAE KFKEE 215 |
Gene Ontology | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IDA:SGD. GO:0008379; F:thioredoxin peroxidase activity; IDA:SGD. GO:0045454; P:cell redox homeostasis; IDA:SGD. GO:0034599; P:cellular response to oxidative stress; IGI:SGD. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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