CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023727
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein MTO1 homolog, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 MTO1 
Gene Synonyms/Alias
 CGI-02 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
86PSFGGIGKGHLMREVubiquitination[1]
112DQSGVHYKVLNRRKGubiquitination[1]
118YKVLNRRKGPAVWGLubiquitination[1]
170PEPEHTGKCRVSGVVubiquitination[1]
227GLAQTLEKLGFVVGRubiquitination[1]
245GTPPRIAKESINFSIubiquitination[1]
297RVDEIVLKNLHLNSHubiquitination[1, 2]
306LHLNSHVKETTRGPRubiquitination[1]
321YCPSIESKVLRFPNRubiquitination[1]
372IRGLEKAKVIQPGYGubiquitination[1]
475ASLRVSRKPPFVVSRubiquitination[1]
531RLTLRGYKDAGCVSQubiquitination[1]
548YERACWMKSSLEEGIubiquitination[1]
559EEGISVLKSIEFLSSubiquitination[1]
567SIEFLSSKWKKLIPEubiquitination[1]
570FLSSKWKKLIPEASIubiquitination[1, 2]
592VRALDVLKYEEVDMDubiquitination[1]
611AVPEPLKKYTKCRELubiquitination[1]
652DEALQLPKDLDYLTIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. 
Sequence Annotation
 NP_BIND 43 48 FAD (By similarity).  
Keyword
 Alternative splicing; Cardiomyopathy; Complete proteome; Disease mutation; FAD; Flavoprotein; Mitochondrion; Reference proteome; Transit peptide; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 717 AA 
Protein Sequence
MFYFRGCGRW VAVSFTKQQF PLARLSSDSA APRTPHFDVI VIGGGHAGTE AATAAARCGS 60
RTLLLTHRVD TIGQMSCNPS FGGIGKGHLM REVDALDGLC SRICDQSGVH YKVLNRRKGP 120
AVWGLRAQID RKLYKQNMQK EILNTPLLTV QEGAVEDLIL TEPEPEHTGK CRVSGVVLVD 180
GSTVYAESVI LTTGTFLRGM IVIGLETHPA GRLGDQPSIG LAQTLEKLGF VVGRLKTGTP 240
PRIAKESINF SILNKHIPDN PSIPFSFTNE TVWIKPEDQL PCYLTHTNPR VDEIVLKNLH 300
LNSHVKETTR GPRYCPSIES KVLRFPNRLH QVWLEPEGMD SDLIYPQGLS MTLPAELQEK 360
MITCIRGLEK AKVIQPGYGV QYDYLDPRQI TPSLETHLVQ RLFFAGQING TTGYEEAAAQ 420
TECCSVARLE CSDMISQLQA ILLPQPSLVA GTAGMHHNTQ GVIAGINASL RVSRKPPFVV 480
SRTEGYIGVL IDDLTTLGTS EPYRMFTSRV EFRLSLRPDN ADSRLTLRGY KDAGCVSQQR 540
YERACWMKSS LEEGISVLKS IEFLSSKWKK LIPEASISTS RSLPVRALDV LKYEEVDMDS 600
LAKAVPEPLK KYTKCRELAE RLKIEATYES VLFHQLQEIK GVQQDEALQL PKDLDYLTIR 660
DVSLSHEVRE KLHFSRPQTI GAASRIPGVT PAAIINLLRF VKTTQRRQSA MNESSKTDQY 720
LCDADRLQER EL 732 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0070899; P:mitochondrial tRNA wobble uridine modification; IEA:Compara.
 GO:0055114; P:oxidation-reduction process; IEA:InterPro. 
Interpro
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR026904; GidA-assoc_3.
 IPR002218; GIDA-rel.
 IPR020595; GIDA-rel_CS. 
Pfam
 PF01134; GIDA
 PF13932; GIDA_assoc_3 
SMART
  
PROSITE
 PS01280; GIDA_1
 PS01281; GIDA_2 
PRINTS
 PR00368; FADPNR.