UniProt Accession

 PAR6B_MOUSE; Q9JK83; A2ANX8; Q8R3J8 

Genbank Protein ID

 AF252291; AL831766; CH466551; BC025147 

Genbank Nucleotide ID

 AAF71528.1; CAM17536.1; EDL06536.1; AAH25147.1 

Protein Name

 Partitioning defective 6 homolog beta 

Protein Synonyms/Alias

 PAR-6 beta; PAR-6B 

Gene Name

 Pard6b 

Gene Synonyms/Alias

 Par6b 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
95	LLRIFIQKKEEADYS	acetylation	[1]
188	VTPHGLEKVPGIFIS	ubiquitination	[2]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. 

Sequence Annotation

 DOMAIN 16 96 OPR.
 DOMAIN 133 150 Pseudo-CRIB.
 DOMAIN 157 250 PDZ.
 REGION 126 253 Interaction with PARD3 and CDC42.
 MOD_RES 11 11 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Cell cycle; Cell division; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome; Tight junction. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 371 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IDA:MGI.
 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005923; C:tight junction; ISS:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006461; P:protein complex assembly; ISS:UniProtKB. 

Interpro

 IPR000270; OPR_PB1.
 IPR001478; PDZ. 

Pfam

 PF00564; PB1
 PF00595; PDZ 

SMART

 SM00666; PB1
 SM00228; PDZ 

PROSITE

 PS50106; PDZ 

PRINTS