UniProt Accession

 ADH1B_HUMAN; P00325; Q13711; Q4ZGI9; Q96KI7 

Genbank Protein ID

 M24317; X03350; M24316; M24308; M24309; M24310; M24311; M24312; M24313; M24314; D00137; L38290; L38283; L38284; L38285; L38286; L38287; L38288; L38289; X15447; X15448; X15449; X15450; X15451; X15452; X15453; X15454; X15455; AF153821; DQ017646; BC033009; M21692; AF040967 

Genbank Nucleotide ID

 AAA51884.1; CAA27056.1; AAB59496.1; AAB59496.1; AAB59496.1; AAB59496.1; AAB59496.1; AAB59496.1; AAB59496.1; AAB59496.1; BAA00084.1; AAB48003.1; AAB48003.1; AAB48003.1; AAB48003.1; AAB48003.1; AAB48003.1; AAB48003.1; AAB48003.1; CAA33487.1; CAA33487.1; CAA33487.1; CAA33487.1; CAA33487.1; CAA33487.1; CAA33487.1; CAA33487.1; CAA33487.1; AAD37446.1; AAY22180.1; AAH33009.1; AAA51592.1; AAB96912.1 

Protein Name

 Alcohol dehydrogenase 1B 

Protein Synonyms/Alias

 Alcohol dehydrogenase subunit beta 

Gene Name

 ADH1B 

Gene Synonyms/Alias

 ADH2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	AGKVIKCKAAVLWEV	glycation	[1]
40	KAYEVRIKMVAVGIC	glycation	[1]
232	INKDKFAKAKELGAT	glycation	[1]
249	INPQDYKKPIQEVLK	glycation	[1]
326	VYGGFKSKEGIPKLV	glycation	[1]
355	THVLPFEKINEGFDL	acetylation	[2]

Reference

 [1] Sites of glycation of human and horse liver alcohol dehydrogenase in vivo.
 Shilton BH, Walton DJ.
 J Biol Chem. 1991 Mar 25;266(9):5587-92. [PMID: 2005099]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

  

Sequence Annotation

 NP_BIND 200 205 NAD.
 NP_BIND 293 295 NAD.
 METAL 47 47 Zinc 1; catalytic.
 METAL 68 68 Zinc 1; catalytic.
 METAL 98 98 Zinc 2.
 METAL 101 101 Zinc 2.
 METAL 104 104 Zinc 2.
 METAL 112 112 Zinc 2.
 METAL 175 175 Zinc 1; catalytic.
 BINDING 224 224 NAD.
 BINDING 229 229 NAD.
 BINDING 370 370 NAD.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Metal-binding; NAD; Oxidoreductase; Polymorphism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 375 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004024; F:alcohol dehydrogenase activity, zinc-dependent; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IDA:UniProtKB.
 GO:0006069; P:ethanol oxidation; IDA:UniProtKB.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS00059; ADH_ZINC 

PRINTS