CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025816
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fibroblast growth factor receptor 4 variant 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
640RPPATVQKLSRFPLAubiquitination[1]
703RDRLVLGKPLGEGCFubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1034 AA 
Protein Sequence
PCMWHQQHVP CVCVCPYVCV CMRVCVCVCV SWPLSCALNA VCVTCPKSVA FALGVASAAC 60
GCVGVKEWWL LQHALRSACA LHVRCVLCTQ EAASDGAAGS ADLCPLPTEP CLAPSLEQQE 120
QELTVALGQP VRLCCGRAER GGHWYKEGSR LAPAGRVRGW RGRLEIASFL PEDAGRYLCL 180
ARGSMIVLQN LTLITGDSLP PATMMRTPSP IGTSRIGTVT PSKVSRSPRT CVPAAAHLIT 240
EKRRPVWEHT VILGAFPCPP APYWTHPQRM EKKLHAVPAG NTVKFRCPAA GNPTPTIRWL 300
KDGQAFHGEN RIGGIRLRHQ HWSLVMESVV PSDRGTYTCL VENAVGSIRY NYLLDVLERS 360
PHRPILQAGL PANTTAVVGS DVELLCKVYS DAQPHIQWLK HIVINGSSFG ADGFPYVQVL 420
KTADINSSEV EVLYLRNVSA EDAGEYTCLA GNSIGLSYQS AWLTVLPGEH LKGQEMLRDA 480
PLGQQWGLWP VGWSVSVGLW GLAWGAVCGF VGLSCMTAPL CLSTRGRPCD RLLRCGCLGL 540
GITTASSVCV PTYVGSWEGL SGCTGRPVSP LTSLSVCVCP CARAEEDPTW TAAAPEARYT 600
DIILYASGSL ALAVLLLLAR LYRGQALHGR HPRPPATVQK LSRFPLARQF SLESGSSGKS 660
SSSLVRGVRL SSSGPALLAG LVSLDLPLDP LWEFPRDRLV LGKPLGEGCF GQVVRAEAFG 720
MDPARPDQAS TVAVKMLKDN ASDKDLADLV SEMEVMKLIG RHKNIINLLG VCTQEGPLYV 780
IVECAAKGNL REFLRARRPP GPDLSPDGPR SSEGPLSFPV LVSCAYQVAR GMQYLESRKC 840
IHRDLAARNV LVTEDNVMKI ADFGLARGVH HIDYYKKTSN GRLPVKWMAP EALFDRVYTH 900
QSDVWSFGIL LWEIFTLGGS PYPGIPVEEL FSLLREGHRM DRPPHCPPEL YGLMRECWHA 960
APSQRPTFKQ LVEALDKVLL AVSEEYLDLR LTFGPYSPSG GDASSTCSSS DSVFSHDPLP 1020
LGSSSFPFGS GVQT 1034 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF07679; I-set
 PF07714; Pkinase_Tyr 
SMART
 SM00408; IGc2
 SM00219; TyrKc 
PROSITE
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.