UniProt Accession

 KCC1D_HUMAN; Q8IU85; B0YIY0; Q9HD31 

Genbank Protein ID

 AF286366; AB081726; EF444962; AL391314; AL512284; AL512783; AL731559; AL512284; AL391314; AL512783; AL731559; AL512284; AL391314; AL512783; AL731559; AL512783; AL391314; AL512284; AL731559; AL512783; AL391314; AL512284; AL731559; AL731559; AL391314; AL512284; AL512783; CH471072; BC035745 

Genbank Nucleotide ID

 AAG00534.1; BAC19846.1; ACA05959.1; CAI14410.1; CAI14410.1; CAI14410.1; CAI14410.1; CAH71693.1; CAH71693.1; CAH71693.1; CAH71693.1; CAH71694.1; CAH71694.1; CAH71694.1; CAH71694.1; CAH74035.1; CAH74035.1; CAH74035.1; CAH74035.1; CAH74036.1; CAH74036.1; CAH74036.1; CAH74036.1; CAI14675.1; CAI14675.1; CAI14675.1; CAI14675.1; EAW86314.1; AAH35745.1 

Protein Name

 Calcium/calmodulin-dependent protein kinase type 1D 

Protein Synonyms/Alias

 CaM kinase I delta; CaM kinase ID; CaM-KI delta; CaMKI delta; CaMKID; CaMKI-like protein kinase; CKLiK 

Gene Name

 CAMK1D 

Gene Synonyms/Alias

 CAMKID 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
52	TGKLFAVKCIPKKAL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine- induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. 

Sequence Annotation

 DOMAIN 23 279 Protein kinase.
 NP_BIND 29 37 ATP (By similarity).
 REGION 279 319 Autoinhibitory domain (By similarity).
 REGION 299 320 Calmodulin-binding (By similarity).
 MOTIF 318 324 Nuclear export signal (By similarity).
 ACT_SITE 144 144 Proton acceptor (By similarity).
 BINDING 52 52 ATP (By similarity).
 MOD_RES 122 122 Phosphoserine.
 MOD_RES 180 180 Phosphothreonine; by CaMKK1 and CaMKK2.  

Keyword

 3D-structure; Allosteric enzyme; Alternative splicing; ATP-binding; Calcium; Calmodulin-binding; Complete proteome; Cytoplasm; Inflammatory response; Kinase; Neurogenesis; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 385 AA 

Protein Sequence

Gene Ontology

 GO:0005954; C:calcium- and calmodulin-dependent protein kinase complex; TAS:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0032793; P:positive regulation of CREB transcription factor activity; IDA:UniProtKB.
 GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.
 GO:0090023; P:positive regulation of neutrophil chemotaxis; ISS:UniProtKB.
 GO:0050766; P:positive regulation of phagocytosis; IMP:UniProtKB.
 GO:0060267; P:positive regulation of respiratory burst; IMP:UniProtKB.
 GO:0042981; P:regulation of apoptotic process; IEA:Compara.
 GO:0050773; P:regulation of dendrite development; IMP:UniProtKB. 

Interpro

 IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS