CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014823
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Small kinetochore-associated protein 
Protein Synonyms/Alias
 SKAP; Kinetochore-localized astrin-binding protein; Kinastrin; Kinetochore-localized astrin/SPAG5-binding protein; TRAF4-associated factor 1 
Gene Name
 Knstrn 
Gene Synonyms/Alias
 Skap; Traf4af1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
115SKLPVKSKDAEMLRHacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (By similarity). 
Sequence Annotation
 REGION 156 312 Interaction with SPAG5 (By similarity).  
Keyword
 Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 312 AA 
Protein Sequence
MATHKAEAQE TDFRTTGPPT DLEQCPFPPS SRKFPFESVA ADSTEGWAVA AEHHLKRSGE 60
DGGWEQPASG VEPSRPTTMA SSKTVCDAQP HSMPSCGLSA DTQTRATSKL PVKSKDAEML 120
RHLHTGGLEP DVTKVTKPRR ENGQGKAAET ASRRNIRSSY KPLSKQKPEE DLKDKNELLE 180
AVNKQLHQKL TETQGELKDL TQKVELLEKF QDNCLAILES KGLNSGQETQ ESKQEPSTDP 240
TDSMLLLETL KDELKLFNET AKKQMEELQA LKVKLKLKEK ERIQFLEQQT LGKDEASDFT 300
IILEEMEQLL EM 312 
Gene Ontology
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0000776; C:kinetochore; ISS:UniProtKB.
 GO:0035371; C:microtubule plus end; ISS:UniProtKB.
 GO:0072686; C:mitotic spindle; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0000090; P:mitotic anaphase; ISS:UniProtKB.
 GO:0000070; P:mitotic sister chromatid segregation; ISS:UniProtKB.
 GO:0051988; P:regulation of attachment of spindle microtubules to kinetochore; ISS:UniProtKB.
 GO:0007051; P:spindle organization; ISS:UniProtKB. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS