CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015220
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 549 
Protein Synonyms/Alias
  
Gene Name
 ZNF549 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
485CGKAFISKQTLLKHHubiquitination[1]
508YECSECGKGFYLEVKacetylation[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 27 140 KRAB.
 ZN_FING 217 241 C2H2-type 1; degenerate.
 ZN_FING 247 269 C2H2-type 2; degenerate.
 ZN_FING 275 298 C2H2-type 3.
 ZN_FING 304 326 C2H2-type 4.
 ZN_FING 332 355 C2H2-type 5.
 ZN_FING 361 383 C2H2-type 6.
 ZN_FING 389 411 C2H2-type 7.
 ZN_FING 417 439 C2H2-type 8.
 ZN_FING 445 467 C2H2-type 9.
 ZN_FING 473 495 C2H2-type 10.
 ZN_FING 501 523 C2H2-type 11.
 ZN_FING 529 551 C2H2-type 12.
 ZN_FING 557 579 C2H2-type 13.
 ZN_FING 585 607 C2H2-type 14.
 ZN_FING 613 635 C2H2-type 15.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 640 AA 
Protein Sequence
MAEAALVITP QIPMVTEEFV KPSQGHVTFE DIAVYFSQEE WGLLDEAQRC LYHDVMLENF 60
SLMASVGCLH GIEAEEAPSE QTLSAQGVSQ ARTPKLGPSI PNAHSCEMCI LVMKDILYLS 120
EHQGTLPWQK PYTSVASGKW FSFGSNLQQH QNQDSGEKHI RKEESSALLL NSCKIPLSDN 180
LFPCKDVEKD FPTILGLLQH QTTHSRQEYA HRSRETFQQR RYKCEQVFNE KVHVTEHQRV 240
HTGEKAYKRR EYGKSLNSKY LFVEHQRTHN AEKPYVCNIC GKSFLHKQTL VGHQQRIHTR 300
ERSYVCIECG KSLSSKYSLV EHQRTHNGEK PYVCNVCGKS FRHKQTFVGH QQRIHTGERP 360
YVCMECGKSF IHSYDRIRHQ RVHTGEGAYQ CSECGKSFIY KQSLLDHHRI HTGERPYECK 420
ECGKAFIHKK RLLEHQRIHT GEKPYVCIIC GKSFIRSSDY MRHQRIHTGE RAYECSDCGK 480
AFISKQTLLK HHKIHTRERP YECSECGKGF YLEVKLLQHQ RIHTREQLCE CNECGKVFSH 540
QKRLLEHQKV HTGEKPCECS ECGKCFRHRT SLIQHQKVHS GERPYNCTAC EKAFIYKNKL 600
VEHQRIHTGE KPYECGKCGK AFNKRYSLVR HQKVHITEEP 640 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS