CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038077
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Usp24 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
31RKALRLAKNDINEAVubiquitination[1]
149KREESLGKCLLASTYubiquitination[1]
419IEDSTLSKSVKNAIDubiquitination[1]
646EITRSFIKQTYQKQDubiquitination[1]
654QTYQKQDKSIIQDLKubiquitination[1]
1126LDSLGRKKTLLSETSubiquitination[1]
1138ETSSQSSKSPSLSSKubiquitination[1]
1182NLEVLSSKLMPTADDubiquitination[1]
1354VGSSQPIKESNSLFPubiquitination[1]
1625SQQDFHPKCSTVNSRubiquitination[1]
1762KIFKMWNKELYVREQubiquitination[1]
1808QGIYSDQKICKDCPHubiquitination[1]
1859SNAYYCEKCKEKRITubiquitination[1]
2507FLVTLAQKCPAAKEYubiquitination[1]
2552SNETSTGKTFQRTISubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2618 AA 
Protein Sequence
MESEEEQHMT TLLCMGFSDP ATIRKALRLA KNDINEAVAL LTNERPGLDY GGYEPMDSGG 60
PSPGPGGGPR GDSGSDGSGP SRGGSTGGGG GFDPPPAYHE VVDAEKNDEN GNCSGEGIEF 120
PTTNLYELES RVLTDHWSIP YKREESLGKC LLASTYLARL GLSESDENCK RFMERCMPEA 180
FKKLLTSSAV HKWGTEIHEG IYNMLMLLIE LVAERMKQDP IPIGLLGVLT MAFNPDNEYH 240
FKNRMKVSQR NWAEVFGEGN MFAISPVSTF QKEPHGWVVD LVNKFGELGG FAAIQAKLHS 300
EDIELGAVSA LVQPLGVCAE YLNSSVVQPM LDPVILTTIQ DVRSVEEKDL KDKKRLVSIP 360
ELLSAIKLLC MRFQPALVTT VDALRLDILL RMLKSPHFSA KMNSLKEVTK LIEDSTLSKS 420
VKNAIDTDRL LDWLVENSVL SIALEGNIDQ AQYCDRIKGI IELLGSKLSL DELTKIWKIQ 480
SGQSSTVIEN IHTIIAAAAV KFNADQLNHL FVLIQKSWET ESDRVRQKLL SLIGRIGREA 540
RFEATSGKVL DVLWELAHLP TLPSSLIQQA LEEHLTILSD AYAVKEAVKR SYIIKCIEDI 600
KRPGEWSSLE KNKKDGFKSS QLNNPQFVWV VPALRQLHEI TRSFIKQTYQ KQDKSIIQDL 660
KKNFEIVKLV TGSLLACHRL AAAVAGPGGL TGLTLVDGRY TYREYLEAHL KFLAFFLQEA 720
TLYLGWNRAK EIWECLVTGQ DVCELDREMC FEWFTKGQHD LESDVQQQLF KEKILKLESY 780
EITMNGFNLF KTFFENVNLC DHRLKRQGAQ LYVEKLELVG MDFIWKIAME SPDEEIANEA 840
IQLIINYSYI NLNPRLKKDS VSLHKKFIAD CYTRLEAASS ALGGPTLTHA VTRATKMLTA 900
TAMPTVATSV QSPYRSTKLV IIERLLLLAE RYVITIEDFY SVPRTILPHG ASFHGHLLTL 960
NVTYESTKDT FTVEAHSNET IGSVRWKIAK QLCSPVDNIQ IFTNDSLLTV NKDQKLLHQL 1020
GFSDEQVLTV KTSGSGTPSG SSADSSTSSS SSSSGAFSSS YAMEQEKSLP GVVMALVCNV 1080
FDMLYQLANL EEPRITLRVR KLLLLIPTDP AIQEALDQLD SLGRKKTLLS ETSSQSSKSP 1140
SLSSKQQHQP SASSILESLF RSFAPGMSTF RVLYNLEVLS SKLMPTADDD MARSCAKSFC 1200
ENFLKAGGLS LVVNVMQRDS IPSEVDYETR QGVYSICLQL ARFLLVGQTM PTSLDEDLTK 1260
DGIEALSSRP FRNVSRQTSR QMSLCGTPEK SSYRQLSVSD RSSIRVEEII PAARVAIQTM 1320
EASDFTATVA CFMRLSWAAA AGRLDLVGSS QPIKESNSLF PAGIRSRLSS SGSNCSSSSE 1380
GEPAALHAGI CVRQQSVSTK DALIAGEALS LLVTCLQLRS QQLASFYSLP CVADFIIDIL 1440
LGSPSAEIRR VACDQLYTLS QTDTSAHPEV QKPNQFLLGV ILTAQLPLWS PTSIMRGVNQ 1500
RLLSQCMEYF DLRCQLLDDL TTSEMDQLRI SPATMLEDEI TWLDNFEPNR TADCETSEAD 1560
NILLAGHLRL IKTLLSLCGA EKEMLGSSLI KPLLDDFLFR ASRIIVNSHS PASSAAISQQ 1620
DFHPKCSTVN SRLAAYEVLV MLADSSPSNL QIITKELLSM HHQPDPALTK EFDYLPPVDS 1680
RSSSGFVGLR NGGATCYMNA VFQQLYMQPG LPESLLSVDD DTDNPDDSVF YQVQSLFGHL 1740
MESKLQYYVP ENFWKIFKMW NKELYVREQQ DAYEFFTSLI DQMDEYLKKM GREQIFKNTF 1800
QGIYSDQKIC KDCPHRYERE EAFMALNLGV TSCQSLEISL DQFVRGEVLE GSNAYYCEKC 1860
KEKRITVKRT CIKSLPSVLV IHLMRFGFDW ESGRSIKYDE QIRFPWMLNM EPYTVAGMAR 1920
QDSSSEVGEN GRNMDQGGGG SPRKKVALTE NYELVGVIVH SGQAHAGHYY SFIKDRRGCG 1980
KGKWYKFNDT VIEEFDLNDE TLEYECFGGE YRPKVYDQTN PYTDVRRRYW NAYMLFYQRV 2040
SDQNSPVLPK KSRVSVVRQE AEDLSLSAPS SPEISPQSSP RPHRPNNDRL SILTKLVKKG 2100
EKKGLFVEKM PARIYQMVRD ENLKFMKNRD VYSSDYFSFV LSLASLNATK LKHPYYPCMA 2160
KVSLQLAIQF LFQTYLRTKK KLRVDTEEWI ATIEALLSKS LDACQWLVEY FISSEGRELV 2220
KVFLLECSVR EVRVAVATIL EKTLDSALFY QDKLKSLHQL LEVLLALLDK DVPENCKNCA 2280
QYFSLFNTFV QKQGIRAGDL LLRHSALRHM ISFLLGVSRQ NSQIRRWSSA QAREFGNLHN 2340
TVALLVLHSD VSSQRNVAPG IFKQRPPISV APSSPLLPLH EEVEALLFLS EGKPYLLEVM 2400
FALRELTGSL LALMEMVVYC CFCNEHFSFT MLHFIKNQLE TAPPHELKNT FQLLHEVLVI 2460
EDPIQVERVK FVFETENGLL ALMHHSNHVD SSRCYQCVKF LVTLAQKCPA AKEYFKENSH 2520
HWSWAVQWLQ KKMSEHYWTP QSNVSNETST GKTFQRTISA QDTLAYATAL LNEKEQSGSS 2580
NGSESSPANE NGERHLQQGS ESPMMIGELR SDLDDVDP 2618 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19.
 IPR009060; UBA-like.
 IPR015940; UBA/transl_elong_EF1B_N_euk. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS50030; UBA
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS