UniProt Accession

 MS3L1_HUMAN; Q8N5Y2; A6NCU2; A6NHW8; A8K165; B4DUV8; Q9UG70; Q9Y5Z8 

Genbank Protein ID

 AF117065; AK025642; AK289780; AK300814; AC004554; CH471074; CH471074; BC031210; AL050178; AL713667 

Genbank Nucleotide ID

 AAD38499.1; BAF82469.1; BAG62470.1; EAW98799.1; EAW98801.1; AAH31210.1; CAB43308.1; CAD28473.1 

Protein Name

 Male-specific lethal 3 homolog 

Protein Synonyms/Alias

 Male-specific lethal-3 homolog 1; Male-specific lethal-3 protein-like 1; MSL3-like 1 

Gene Name

 MSL3 

Gene Synonyms/Alias

 MSL3L1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
289	YKKVTSSKFFLPIKE	ubiquitination	[1, 2]
295	SKFFLPIKESATSTN	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. 

Sequence Annotation

 DOMAIN 32 90 Chromo.
 DOMAIN 168 517 MRG.
 MOD_RES 311 311 Phosphoserine.
 MOD_RES 367 367 Phosphoserine.
 MOD_RES 400 400 Phosphoserine.
 MOD_RES 405 405 Phosphothreonine.
 MOD_RES 407 407 Phosphoserine.
 MOD_RES 411 411 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Chromatin regulator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 521 AA 

Protein Sequence

Gene Ontology

 GO:0072487; C:MSL complex; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0035064; F:methylated histone residue binding; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0043984; P:histone H4-K16 acetylation; IDA:UniProtKB.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR000953; Chromo_domain/shadow.
 IPR016197; Chromodomain-like.
 IPR008676; MRG.
 IPR026541; MRG_dom.
 IPR025995; Tudor-knot. 

Pfam

 PF05712; MRG
 PF11717; Tudor-knot 

SMART

 SM00298; CHROMO 

PROSITE

 PS00598; CHROMO_1
 PS50013; CHROMO_2
 PS51640; MRG 

PRINTS