CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037931
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear pore complex protein Nup160 
Protein Synonyms/Alias
  
Gene Name
 NUP160 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
17LNNAIRLKFQNCSVLubiquitination[1, 2, 3]
144MVSVVELKQSSVMQRubiquitination[1, 2, 4, 5]
193FALCQDHKLRMWSYKubiquitination[1]
217MLEYVPVKKDLRLTAubiquitination[1]
229LTAGTGHKLRLAYSPubiquitination[2, 3]
381DLSWSELKKEVTLAVubiquitination[1, 2, 4, 5]
382LSWSELKKEVTLAVEubiquitination[2, 3]
447TNMVCLLKKGYLSFLubiquitination[1]
494RDVICLIKCLRLIEEubiquitination[1, 3]
575ETEVEMEKGFNPAQPubiquitination[1, 2, 3, 4, 5]
608IVCRGVHKIASTRFLubiquitination[1]
719FFQEVARKHIISHLFubiquitination[2]
811LVTGEGQKALECFCQubiquitination[1, 2, 3]
825QAASEVGKEEFLDRLubiquitination[1, 2, 3]
851PRLQYYDKVLRLLDVubiquitination[1, 2, 3, 4, 5, 6, 7, 8]
892TLRTCIFKHHLDLGHubiquitination[1, 2]
982IYRHNYRKAGTVMFEubiquitination[2, 4]
1006RTLRGLEKQGNCYLAubiquitination[1, 2, 3, 8]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [7] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [8] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1037 AA 
Protein Sequence
MEESLDINLL NNAIRLKFQN CSVLPGGVYV SETQNRVIIL MLTNQTVHRL LLPHPSRMYR 60
SELVVDSQMQ SIFTDIGKVD FTDPCNYQLI PAVPGISPNS TASTAWLSSD GEALFALPCA 120
SGGIFVLKLP PYDIPGMVSV VELKQSSVMQ RLLTGWMPTA IRGDQSPSDR PLSLAVHCVE 180
HDAFIFALCQ DHKLRMWSYK EQMCLMVADM LEYVPVKKDL RLTAGTGHKL RLAYSPTMGL 240
YLGIYMHAPK RGQFCIFQLV STESNRYSLD HISSLFTSQE TLIDFALTST DIWALWHDAE 300
NQTVVKYINF EHNVAGQWNP VFMQPLPEEE IVIRDDQDPR EMYLQSLFTP GQFTNEALCK 360
ALQIFCRGTE RNLDLSWSEL KKEVTLAVEN ELQGSVTEYE FSQEEFRNLQ QEFWCKFYAC 420
CLQYQEALSH PLALHLNPHT NMVCLLKKGY LSFLIPSSLV DHLYLLPYEN LLTEDETTIS 480
DDVDIARDVI CLIKCLRLIE ESVTVDMSVI MEMSCYNLQS PEKAAEQILE DMITIDVENV 540
MEDICSKLQE IRNPIHAIGL LIREMDYETE VEMEKGFNPA QPLNIRMNLT QLYGSNTAGY 600
IVCRGVHKIA STRFLICRDL LILQQLLMRL GDAVIWGTGQ LFQAQQDLLH RTAPLLLSYY 660
LIKWGSECLA TDVPLDTLES NLQHLSVLEL TDSGALMANR FVSSPQTIVE LFFQEVARKH 720
IISHLFSQPK APLSQTGLNW PEMITAITSY LLQLLWPSNP GCLFLECLMG NCQYVQLQDY 780
IQLLHPWCQV NVGSCRFMLG RCYLVTGEGQ KALECFCQAA SEVGKEEFLD RLIRSEDGEI 840
VSTPRLQYYD KVLRLLDVIG LPELVIQLAT SAITEAGDDW KSQATLRTCI FKHHLDLGHN 900
SQAYEALTQI PDSSRQLDCL RQLVVVLCER SQLQDLVEFP YVNLHNEVVG IIESRARAVD 960
LMTHNYYELL YAFHIYRHNY RKAGTVMFEY GMRLGREVRT LRGLEKQGNC YLAALNCLRL 1020
IRPEYAWIVQ PVSGAVV 1037 
Gene Ontology
  
Interpro
 IPR021717; Nucleoporin_Nup160. 
Pfam
 PF11715; Nup160 
SMART
  
PROSITE
  
PRINTS