UniProt Accession

 CSRA_ECOLI; P69913; P31803 

Genbank Protein ID

 L07596; D44453; U00096; AP009048 

Genbank Nucleotide ID

 AAA71919.1; BAA21555.1; AAC75738.1; BAA16558.1 

Protein Name

 Carbon storage regulator 

Protein Synonyms/Alias

  

Gene Name

 csrA 

Gene Synonyms/Alias

 zfiA; b2696; JW2666 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
38	RIGVNAPKEVSVHRE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Binds to mRNA to regulate post-transcriptional activity. Affects glycogen biosynthesis, gluconeogenesis, cell size and surface properties. Regulates glycogen synthesis under both aerobic and anaerobic conditions. Seems to accelerate the degradation of glg gene transcripts, potentially through selective RNA binding. Acts to inhibit interaction between the LetD protein and the A subunit of DNA gyrase. Also required for motility and flagellum biosynthesis through the post-transcriptional activation of flhDC expression. This involves binding to and stabilization of the flhDC message by CsrA. Binds to and reduces levels of probable diguanylate cyclases ycdT and ydeH. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 61 AA 

Protein Sequence

Gene Ontology

 GO:0048027; F:mRNA 5'-UTR binding; IDA:EcoCyc.
 GO:0006402; P:mRNA catabolic process; IEA:HAMAP.
 GO:0045719; P:negative regulation of glycogen biosynthetic process; IDA:EcoCyc.
 GO:0045947; P:negative regulation of translational initiation; IDA:EcoCyc. 

Interpro

 IPR003751; CsrA. 

Pfam

 PF02599; CsrA 

SMART

  

PROSITE

  

PRINTS