CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029661
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ADP-ribosylation factor-binding protein GGA1 
Protein Synonyms/Alias
  
Gene Name
 GGA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
93LIKVVSPKYLGSRTSubiquitination[1, 2, 3]
133EAYQMLKKQGIVKSDubiquitination[2]
157PLPPPRPKNVIFEDEubiquitination[1, 2, 3, 4, 5, 6]
166VIFEDEEKSKMLARLubiquitination[2, 4]
168FEDEEKSKMLARLLKubiquitination[3]
175KMLARLLKSSHPEDLubiquitination[2, 3]
190RAANKLIKEMVQEDQubiquitination[2, 3, 4]
198EMVQEDQKRMEKISKubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 246 AA 
Protein Sequence
MTPGTANRAT NPLNKELDWA SINGFCEQLN EDFEGPPLAT RLLAHKIQSP QEWEAIQALT 60
VLETCMKSCG KRFHDEVGKF RFLNELIKVV SPKYLGSRTS EKVKNKILEL LYSWTVGLPE 120
EVKIAEAYQM LKKQGIVKSD PKLPDDTTFP LPPPRPKNVI FEDEEKSKML ARLLKSSHPE 180
DLRAANKLIK EMVQEDQKRM EKISKRVNAI EEVNNNVKLL TEMVMSHSQG GAAAGSSEDL 240
MKELYQ 246 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR008942; ENTH_VHS.
 IPR004152; GAT.
 IPR002014; VHS.
 IPR018205; VHS_subgr. 
Pfam
 PF03127; GAT
 PF00790; VHS 
SMART
 SM00288; VHS 
PROSITE
 PS50909; GAT
 PS50179; VHS 
PRINTS