CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043979
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Oxysterol-binding protein 
Protein Synonyms/Alias
  
Gene Name
 OSBPL10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
194LPTFILEKRSLLEMYubiquitination[1, 2, 3]
490IDAATEQKRHLEEKQubiquitination[4, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lipid transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 538 AA 
Protein Sequence
XQYSGQLHEV REMMNQVEGQ QKNLVHAIES LPGSGPLTAL DQDLLLLKAT SAATLSCLGE 60
CLNLLQQSVH QAGQPSQKPG ASENILGWHG SKSHSTEQLK NGTLGSLPSA SANITWAILP 120
NSAEDEQTSQ PEPEPNSGSE LVLSEDEKSD NEDKEETELG VMEDQRSIIL HLISQLKLGM 180
DLTKVVLPTF ILEKRSLLEM YADFMAHPDL LLAITAGATP EERVICFVEY YLTAFHEGRK 240
GALAKKPYNP IIGETFHCSW EVPKDRVKPK RTASRSPASC HEHPMADDPS KSYKLRFVAE 300
QVSHHPPISC FYCECEEKRL CVNTHVWTKS KFMGMSVGVS MIGEGVLRLL EHGEEYVFTL 360
PSAYARSILT IPWVELGGKV SINCAKTGYS ATVIFHTKPF YGGKVHRVTA EVKHNPTNTI 420
VCKAHGEWNG TLEFTYNNGE TKVIDTTTLP VYPKKIRPLE KQGPMESRNL WREVTRYLRL 480
GDIDAATEQK RHLEEKQRVE ERKRENLRTP WKPKYFIQEV TLPPVIGPLP RRELVLRG 538 
Gene Ontology
 GO:0006869; P:lipid transport; IEA:UniProtKB-KW. 
Interpro
 IPR000648; Oxysterol-bd.
 IPR018494; Oxysterol-bd_CS. 
Pfam
 PF01237; Oxysterol_BP 
SMART
  
PROSITE
 PS01013; OSBP 
PRINTS