UniProt Accession

 MXI1_HUMAN; P50539; B1ANN7; D3DR25; D3DRA9; Q15887; Q6FHW2; Q96E53 

Genbank Protein ID

 L07648; U32515; U32512; U32513; U32514; D63940; BT007069; CR536576; AL360182; AL360182; AL360182; AL360182; CH471066; CH471066; CH471066; CH471066; CH471066; BC012907; BC035128; S78470 

Genbank Nucleotide ID

 AAA75508.1; AAC50446.1; AAC50446.1; AAC50446.1; AAC50446.1; BAA09972.1; AAP35732.1; CAG38813.1; CAI15475.1; CAI15476.1; CAI15479.1; CAI15480.1; EAW49565.1; EAW49567.1; EAW49568.1; EAW49569.1; EAW49570.1; AAH12907.1; AAH35128.2; AAD14282.1 

Protein Name

 Max-interacting protein 1 

Protein Synonyms/Alias

 Max interactor 1; Class C basic helix-loop-helix protein 11; bHLHc11 

Gene Name

 MXI1 

Gene Synonyms/Alias

 BHLHC11 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
125	KLEEAERKSQHQLEN	ubiquitination	[1]

Reference

 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. 

Sequence Annotation

 DOMAIN 67 119 bHLH.  

Keyword

 Alternative splicing; Complete proteome; Disease mutation; DNA-binding; Nucleus; Proto-oncogene; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 228 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0042994; P:cytoplasmic sequestering of transcription factor; TAS:ProtInc.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011598; bHLH_dom. 

Pfam

 PF00010; HLH 

SMART

 SM00353; HLH 

PROSITE

 PS50888; BHLH 

PRINTS