UniProt Accession

 GNA15_HUMAN; P30679; E9KL40; E9KL47; O75247; Q53XK2 

Genbank Protein ID

 M63904; GU727637; GU727645; AF493904; BT009850; AC005264; AC005262; CH471139; BC013585 

Genbank Nucleotide ID

 AAA35860.1; ADU87639.1; ADU87646.1; AAM12618.1; AAP88852.1; AAC25612.1; AAC25616.1; EAW69338.1; AAH13585.1 

Protein Name

 Guanine nucleotide-binding protein subunit alpha-15 

Protein Synonyms/Alias

 G alpha-15; G-protein subunit alpha-15; Epididymis tissue protein Li 17E; Guanine nucleotide-binding protein subunit alpha-16; G alpha-16; G-protein subunit alpha-16 

Gene Name

 GNA15 

Gene Synonyms/Alias

 GNA16 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
19	WCLTEDEKAAARVDQ	ubiquitination	[1]
37	RILLEQKKQDRGELK	ubiquitination	[1]
55	LGPGESGKSTFIKQM	ubiquitination	[1]
201	EYCFSVQKTNLRIVD	ubiquitination	[1, 2, 3]
213	IVDVGGQKSERKKWI	ubiquitination	[1, 3]
331	VDGPEGSKKGARSRR	ubiquitination	[2, 3]
332	DGPEGSKKGARSRRL	ubiquitination	[1]
354	TDTQNIRKVFKDVRD	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. 

Sequence Annotation

 NP_BIND 49 56 GTP (By similarity).
 NP_BIND 183 189 GTP (By similarity).
 NP_BIND 208 212 GTP (By similarity).
 NP_BIND 277 280 GTP (By similarity).
 METAL 56 56 Magnesium (By similarity).
 METAL 189 189 Magnesium (By similarity).
 BINDING 346 346 GTP; via amide nitrogen (By similarity).
 MOD_RES 186 186 ADP-ribosylarginine; by cholera toxin (By  

Keyword

 ADP-ribosylation; Complete proteome; GTP-binding; Magnesium; Metal-binding; Nucleotide-binding; Polymorphism; Reference proteome; Transducer. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 374 AA 

Protein Sequence

Gene Ontology

 GO:0005834; C:heterotrimeric G-protein complex; NAS:UniProtKB.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0001664; F:G-protein coupled receptor binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; NAS:UniProtKB.
 GO:0003924; F:GTPase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IGI:UniProtKB.
 GO:0007202; P:activation of phospholipase C activity; TAS:ProtInc.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IGI:UniProtKB.
 GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IBA:RefGenome.
 GO:0007207; P:phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway; TAS:ProtInc.
 GO:0030168; P:platelet activation; TAS:Reactome. 

Interpro

 IPR000654; Gprotein_alpha_Q.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00503; G-alpha 

SMART

 SM00275; G_alpha 

PROSITE

  

PRINTS

 PR00318; GPROTEINA.
 PR00442; GPROTEINAQ.